Pathology  -  Neuropathology   -   Neuroimaging
Additions  posted  2007 - 2008
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
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Updated 27/12/15
General and Special Pathology 
e-mails : gradanat@fcm.unicamp.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histological methods
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30/11/08
New Cases of Neuroimaging & Neuropathology: 
M. 43 yr.  Right  parietal astroblastoma Same,  HE Same, IH Same, IH, text
F. 48 yr.  Pseudotumoral demyelinating lesion of   cerebral hemispheric white matter Same,  HE Same,  IH Same,  IH
M. 42 yr.  Chondroma of skull base at petrous apex / cavernous sinus Same, HE, IH,  text F. 67 yr. Necrotic cysticercus cellulosae of cerebral hemisphere - reactional changes in brain tissue  Same, specimen, HE. 
F. 60 yr. Primary dural lymphoma with extracranial extension. 12-year follow-up Same, HE.  Picture: lymphomatous infiltration of temporal muscle Same, IH, text : inflammatory pseudotumor 
F. 43 yr.  Chordoid glioma of third ventricle Same, HE Same, IH, text
...
2/10/08
New Cases of Neuroimaging & Neuropathology: 
F. 15 yr. Bilobed, solid and cystic pilocytic astrocytoma of cerebellum with abundant vascular proliferation  Same, surgical specimen, HE Same, special stains Same, IH
F. 29 yr. Solid-cystic right parietal ganglioglioma with  features of xanthoastrocytoma Same, surgical specimen, smears, scanned histological slides  Same, HE Same, special stains
Same, IH - GFAP  Same, IH - neuronal markers Same, IH - CD34, Ki-67
M. 27 yr. Schwannoma of trigeminal nerve root or of Gasserian ganglion  Same, surgical specimen, HE Same, special stains Same, IH
M. 60 yr.  Widespread cerebral metastases of lung adenocarcinoma  Same, HE Same, IH M. 22 yr.  Two metastases of choriocarcinoma (primary in mediastinum)
Same, surgical specimen, HE Same, IH F. 15 yr. Three metastases of choriocarcinoma (primary in hydatiform mole) Same, surgical specimen
F. 27 yr. Diffusely infiltrating, non contrast enhancing B cell lymphoma Same, HE Same, IH
Neuro Image Bank
»»»
Skull base with dura mater and cranial nerve roots Axial sections of intact head, brain in situ.  Coronal sections of intact head, brain in situ.
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31/7/08
New Cases of Neuroimaging & Neuropathology: 
M. 46 yr. Cystic frontal pilocytic astrocytoma 
with abundant vascular proliferation 
Same, surgical specimen, HE Same, special stains Same, IH - GFAP
Same, VIM, CD34, Ki-67 F. 21 yr. Pilocytic astrocytoma of chiasmatic region and third ventricle Same, smear, HE, IH F. 20 yr. Pilocytic astrocytoma of midbrain 
Same, HE, special stains. Picture: leptomeningeal invasion and desmoplastic reaction Same, IH. Picture: leptomeningeal invasion. M. 68 yr. Pilocytic astrocytoma of midbrain tegmentum and pons with cerebellar extension Same, HE. Picture: tumor invasion of perivascular Virchow-Robin spaces
F. 2 yr 5 m. Frontal ependymoblastoma  Same, HE Same, IH Same, IH, text
M. 56 yr. Subependymoma of lateral ventricle  Same, specimen, HE, special stains Same, IH, text
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10/3/08
Basic Atlas of Human Neuroanatomy

Collaboration of

Dept of Anatomy 
IB - UNICAMP 

Dept of Pathology
FCM - UNICAMP

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6/1/08
New Cases of Neuroimaging & Neuropathology: 
M. 36 yr. 
Anaplastic oligoastrocytoma -  radiation brain necrosis after 5 years. 

Case summary

First MRI, march 2002. Right sided frontoparietal tumor Surgical specimen showing vascular proliferation M. 40 yr.  Same patient after 4 years. Radiation induced demyelinating white matter lesions.  No tumor recurrence
M. 41 yr.  Same, 5 years after surgery - radiation induced pseudotumoral brain necrosis.  Same, surgical specimen, HE Same, special stains Same, immunohistochemistry
F. 43 yr.  Meningioma of optic nerve sheath. Surgical specimen, HE Same, special stains Same, IH F. 56 yr. Another case of meningioma of optic nerve sheath. MRI for comparison
F. 13 yr. Clear cell meningioma of posterior fossa  CT, MRI Same, HE, special stains, text. Same, IH Same, electron microscopy
M. 40 yr. Olfactory neuroblastoma (esthesioneuroblastoma) MRI Same case, surgical specimen, HE. Pictured:  Homer Wright rosette Same, IH for neural markers Same, IH for non-neural markers.  Pictured: sustentacular cells. Text
Same, EM M. 11 m.  Retroperitonial neuroblastoma  metastatic  to skull Same, surgical specimen, HE. Pictured:  Homer Wright rosettes Same, IH 
M. 49 yr. Recurrent ependymoma of  foramen of Luschka, with hyaline core rosettes  Same, HE, special stains Same, IH 
Texts: CD56, CD57
Same, EM
F. 19 yr.  Cellular ependymoma  of posterior horn of lateral ventricle Same, surgical specimen, HE. Same, IH.   Pictured:  dot pattern in labelling for EMA  Same, EM. Pictured:  cilia and microvilli filling ependymal rosette 
Text: cell junctions 
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7/11/07
New Cases of Neuroimaging & Neuropathology:  Diffuse astrocytomas 
Illustrated linked text  (in Portuguese)
F. 47 yr. Small low grade frontal astrocytoma (incidental MRI finding).  M. 35 yr. Small  low grade frontal astrocytoma in premotor area  F. 30 yr. Low grade frontal astrocytoma with early anaplasia (foci of contrast enhancement) M. 44 yr. Poorly circumscribed low grade frontal astrocytoma
M. 36 yr. Recurrent frontobasal low grade astrocytoma, 6 yr followup  M. 7 yr. Low grade solid-cystic  astrocytoma of hemispheric white matter M. 43 yr. Diffuse temporal astrocytoma,  transtentorial herniation and midbrain compression  M. 52 yr.  Diffuse temporal astrocytoma infiltrating brainstem
M. 39 yr.  Diffuse low grade temporal astrocytoma  with anaplastic recurrence after 4 years M. 53 yr.  Paramedian anaplastic astrocytoma with contralateral extension via corpus callosum F. 10 yr. Anaplastic astrocytoma of centrum semiovale F. 54 yr.  Low grade astrocytoma of insular region
M. 34 yr.  Low grade astrocytoma of insular region M. 38 yr.  Low grade astrocytoma of insular region F. 40 yr.  Low grade astrocytoma of insular region extending into frontal and temporal lobes M. 52 yr.  Low grade astrocytoma of thalamus with secondary infiltration of hippocampus and insula
M. 5 yr. Diffuse low grade astrocytoma of thalamus and basal ganglia F. 51 yr. Low grade astrocytoma of left thalamus extending into centrum semiovale, corpus callosum and right hippocampus F. 43 yr.  Bilateral thalamic astrocytoma M. 37 yr.  Anaplastic thalamic astrocytoma
F. 46 yr. Low grade periaqueductal astrocytoma  M. 21 yr.  Low grade periaqueductal astrocytoma  M. 8 yr.  Anaplastic  astrocytoma of pons F. 41 yr.  Low grade astrocytoma of pons and medulla
F. 11 yr.  Exophytic anaplastic  astrocytoma of lateral medulla oblongata M. 32yr.  Low grade astrocytoma of cervical spinal cord F. 30 yr. Low grade frontal astrocytoma with early anaplasia. Surgical specimen, HE  Same, IH
Illustrated text linked to cases:

Diffuse astrocytomas

(in Portuguese)

M. 38 yr. Well circumscribed frontal oligoastrocytoma  Same case, surgical specimen, HE Same, IH
....
27/7/2007
New Cases of Neuroimaging & Neuropathology:
Illustrated texts 
(in Portuguese) : 

Sturge-Weber

Sickle cell disease

F. 50 yr.  Sturge-Weber syndrome.  Calcifications in plain skull X-ray films M. 12 yr. Sturge-Weber syndrome.  Cortical calcifications  showing as bands of low signal intensity in T2 WI M. 1 yr 9 m. Sturge- Weber syndrome.  Contrast enhancement of cortical angiomas and choroid plexus in left hemisphere. 
F. 25 yr.  Sickle cell disease.  Infarcts of both middle cerebral artery territories. M. 13 yr.  Sickle cell disease.  Infarcts of carotid artery territories. Pictured : bilateral absence of carotid flow on MRA.  M. 22 yr.  Sickle cell disease.  Infarct of left middle cerebral artery territory F. 19 yr.  Sickle cell disease. Multiple infarts, arterial watershed zone  lesions
F. 27 yr.  Sickle cell disease. Arterial watershed zone lesions in white matter, with cavitations M. 31 yr.  Sickle cell disease. Arterial watershed zone lesions M. 18 yr.  Sickle cell disease. Lacunae in basal ganglia. Arterial watershed zone lesions M. 6 m. Sickle cell disease. Extensive hemorrhagic infarction of cerebellar cortex 
Papillary craniopharyngioma Same, HE.  Squamous epithelium Papillary craniopharyngioma (another case) Same, HE.  Cubic epithelium
Heavily calcified 
oligodendroglioma, 7-year follow up. 
CT (2000 - 2006)
Same, MRI (2006). Diffuse infiltrative growth, invasion of right hemisphere via corpus callosum Same, after 8 months (2007). Development of  contrast enhancing anaplastic foci Same, HE. Oligodendroglioma with minigemistocytes
Case  summary
Same, IH Oligodendroglioma of basal cerebral hemisphere Same. Oligodendroglioma with abundant minigemistocytes, HE, IH Lepromatous leprosy of sural nerve. HE, special stains, IH
Neuro Image Bank
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Normal cerebral digital angiography Normal arterial MRA (magnetic resonance angiography) Normal arterial MRA  (another case)
Normal venous MRA  Normal venous MRA (another case)  Normal temporal artery, HE, Masson's trichrome, Verhoeff
Image Bank, other subjects
»»»
Normal membranous ossification in cranial bones Normal enchondral ossification in vertebral bodies Placenta in maternal sickle cell disease
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30/5/2007
New Cases of Neuroimaging & Neuropathology:
F. 11 yr.  Diffuse astrocytoma of right thalamus with anaplastic foci Same, HE, IH. Pictured: high proportion of positive nuclei  for p53 Secretory meningioma. Electron microscopy. Pictured: pseudopsammomatous bodies Pilocytic astrocytoma of cerebellum rich in Rosenthal fibers. Electron microscopy
F. 6 yr. Gliomatosis cerebri (anaplastic diffuse astrocytoma of rapid growth). 1st  MRI  Same, after 40 days. Multiple foci of contrast enhancement Same, stereotaxic biopsy, HE, IH. Nuclear atypia, endothelial proliferation, thrombosis F. 14 yr. Solid-cystic  temporal
xanthoastrocytoma 
Same, HE, glycogen deposits in tumor cell cytoplasm Same,  PAS Same, IH Same,  EM
F. 18 yr.  Central neurocytoma  Same, HE, IH. Pictured: astrocytic differentiation  F. 75 yr.  Occipital metastasis of follicular carcinoma of thyroid. 4-year history Same, HE, IH
Secretory meningioma of sphenoid wing with hyperostosis. CT, MRI Same, intraosseous, intracranial and intraorbitary components, HE Same, PAS, IH Same, EM
M. 25 yr.  Systemic T/NK cell lymphoma masquerading as multiple sclerosis  Same, postmortem examination of brain and spinal cord Same, brain, HE - lymphoma Same, spinal cord, HE - lymphoma
Case summary Texts: NK cells T/NK lymphomas
Same, spinal cord, HE - other findings. Pictured: cerebellar tonsil herniation down to midthoracic cord Same, spinal cord, IH - lymphoma Same, other organs, HE.  Pictured: lymphomatous infiltration of spleen arterioles Same, endocardium, IH. Pictured: nuclear positivity for Epstein-Barr virus encoded RNAs (EBER)
M. 15 yr.  Non-Taylor cortical dysplasia + incidental pleomorphic
xanthoastrocytoma
Same, temporal lobectomy, gross, HE Same, dysplastic cortex and white matter, HE Same, GFAP. Pictured: gliosis of molecular layer
Case summary
Same, VIM Same, S-100, CD34, NSE. Pictured: abnormal neuron /astrocyte relationship Same, intracortical pleomorphic
xanthoastrocytoma, (chance finding).  HE, IH
Neuro Image Bank
»»»
Massive cerebellar herniation into spinal subarachnoid space down to midthoracic level  Corpora amylacea
.....
2/5/2007
Neuroimaging cases:   Neurofibromatosis  type 1 (NF1) 
M. 23 yr.   NF1.  Diffuse astrocytoma of cerebellum, sphenoid dysplasia, high signal intensity focus in globus pallidus M. 10 yr.   NF1.  Diffuse astrocytoma of optic pathways, gliomatosis of brain stem and cerebral hemispheres
F. 6 yr.   NF1.  Diffuse astrocytoma of optic pathways, gliomatosis of brain stem and centroencephalic structures, neurofibroma of scalp F. 9 yr.   NF1.  Pilocytic astrocytoma of optic nerve
F. 12 yr.   NF1.   Sphenoid dysplasia, neurofibromas of orbit and scalp, enlarged cisterna magna,  foci of abnormal signal intensity in cerebellar vermis and globus pallidus M. 14 yr.   NF1.   Multiple foci of abnormal signal intensity ('hamartomas') in brain. 
F. 25 yr.   NF1.   Foci of abnormal signal intensity ('hamartomas') in brain.  M. 11 yr.   NF1.   Sphenoid dysplasia, neurofibroma of orbit, proptosis, bilateral foci of abnormal signal intensity in globus pallidus
M. 30 yr.   NF1.   Plexiform neurofibroma, sphenoid dysplasia,  middle fossa arachnoid cyst,  craniofacial deformity F. 24 yr.   NF1.   Plexiform neurofibroma of face and scalp, sphenoid dysplasia,  middle fossa  arachnoid cyst,  craniofacial deformity, proptosis and buphthalmos. 
M. 13 yr.   NF1.   Plexiform neurofibroma of scalp and ear,  posterior  fossa arachnoid cyst M. 17 yr.   NF1.   Plexiform neurofibroma of nuchal region with malignant transformation (malignant peripheral nerve sheath tumor, MPNST). 
M. 56 yr.   NF1.   Multiple tumors of spinal nerve roots F. 11 yr.   NF1.   Multiple tumors of spinal roots and nerves extending widely into paravertebral muscles
M. 66 yr.   NF1.   Lateral meningoceles of thoracic and sacral regions, marked kyphoscoliosis, cutaneous neurofibromas.

Neurofibromatosis type 2 (NF2)
M. 11 yr.   NF2.  Bilateral vestibular schwannomas, ependymoma of medulla and cervical cord, meningiomas of foramen of Luschka and lateral ventricle.  M. 25 yr.   NF2.   Bilateral vestibular schwannomas, ependymoma of cervical cord, cavernous sinus meningioma (arrow), optic nerve sheath tumor (also meningioma?)
F. 51 yr.   NF2.  Multiple meningiomas (meningiomatosis), left vestibular schwannoma , ependymoma of spinobulbar transition.
Illustrated linked texts (in Portuguese): schwannomas, neurofibromas,
NF1, NF2.
M. 42 yr.   NF2.   Left vestibular schwannoma, meningioma of petrous apex and sphenoid, tentorial meningioma surrounding straight sinus
Neuro image bank
»»»
Normal skull base and orbit (bone specimens). Normal sphenoid bone Axial CT scan of normal skull base, bone settings
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23/2/2007
New Cases of Pilocytic Astrocytoma  -  Neuroimaging & Neuropathology:
Pilocytic astrocytomas of cerebellum, 3 cases, CT Pilocytic astrocytoma of cerebellar vermis Pilocytic astrocytoma of cerebellar vermis, another case Same, classical biphasic histological pattern.  HE, IH
Pilocytic astrocytoma of cerebellar hemisphere  Pilocytic astrocytoma of cerebellar hemisphere Pilocytic astrocytoma of cerebellar hemisphere. 17-year follow-up Intraventricular
pilocytic astrocytoma
Infiltrating cystic pilocytic astrocytoma of vermis in a 72 year-old man Same, infiltration of cerebellar cortex.  HE, IH Aggressive pilocytic astrocytoma of cerebellum with extensive meningeal infiltration Same, exuberant endothelial proliferation.  HE, IH
Pilocytic astrocytoma of cerebellar vermis with ventricular seeding. 3-year follow-up Same, classical biphasic histological pattern.  HE, IH
Pilocytic astrocytoma of quadrigeminal plate Pilocytic astrocytoma of quadrigeminal plate, another case Pilocytic astrocytoma of optic nerve Pilocytic astrocytoma of optic nerve. Extension to optic chiasm
Pilocytic astrocytoma of hypothalamic region Pilocytic astrocytoma of optic chiasm and hypothalamic region,  anaplastic recurrence  Pilocytic astrocytoma of optic chiasm growing into third ventricle Pilocytic astrocytoma of basal cerebral hemisphere
Pilocytic astrocytoma of optic chiasm with third ventricle extension Same, with pilocytic and fibrillary histological patterns, the latter with gemistocytic astrocytes. HE, IH  Pilocytic astrocytoma of basal cerebral hemisphere recurring after 4 months Same, highly cellular pilocytic pattern
Pilocytic astrocytoma of deep cerebral hemisphere with explosive growth in 4 months Same, pilocytic pattern with intense nuclear atypia Pilocytic astrocytoma of frontal pole Same, exuberant endothelial proliferation.  HE, IH
Pilocytic astrocytoma of thoracic/lumbar spinal cord Same, predominance of diffuse pattern with hyalinized vessels Pilocytic astrocytoma of cervical/thoracic spinal cord Pilocytic astrocytoma of brain stem and cervical spinal cord
Neuro Image Bank
»»»
Illustrated Text:
pilocytic astrocytomas (in English) .
Optic nerve glioma (pilocytic astrocytoma) 
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4/1/2007
New Cases of Neuroimaging & Neuropathology:
Echinococcosis of the central nervous system.  CT, MRI  Same, post mortem examination Same, scanned microscopical slides Same, histology, text
Pseudotumoral multiple sclerosis. CT, MRI Same, scanned microscopical slides, 
HE histology
Same, IH. 
Multiple sclerosis. Acute phase lesions with contrast enhancement Multiple sclerosis.  Typical lesions in corpus callosum and corona radiata Multiple sclerosis. Chronic demyelinating lesions in centrum semiovale Multiple sclerosis. Lesions in corpus callosum and hemispheric white matter
Multiple sclerosis.  Severe case with widespread multifocal demyelination Multiple sclerosis.  Lesions in pons, cerebellum and internal capsule.  Acute disseminated encephalomyelitis (ADEM),  pseudotumoral form
Central pontine myelinolysis Same,  stereotaxic biopsy. Text Central pontine myelinolysis (another case) Osteosarcoma of clivus secondary to irradiation for craniopharyngioma
Same, HE Gliomatosis cerebri initiating as left hemispheric 
oligoastrocytoma. 
Early CT, 6/2004
Same, focus of annular enhancement in right hemisphere. 
MRI 4/2006
Same after two months: tumor dissemination in right hemisphere. 
MRI 6/2006
Ganglioglioma with  sarcomatous component,  CT  Same, MRI Same, HE, special stains Same, IH
Non Langerhans histiocytosis  of skull base and sellar region. Early lesions CT, MRI Same, follow up MRI after 4 months Same, HE, IH Non Langerhans histiocytosis  of meninges and brain. Early lesions, MRI
Same, follow up MRI after 6 months Same, HE, IH Langerhans histiocytosis (eosinophil granuloma) of skull and sternum Same, HE, IH. Text
Neuro Image Bank
»»»
Creutzfeldt-Jakob disease. 
Post mortem examination of brain
Creutzfeldt-Jakob disease.  Another case, 
autopsy findings.
Same, HE. Text
Multiple sclerosis - macroscopical PM specimens Multiple sclerosis - scanned microscopical slides Multiple sclerosis - microscopy Multiple sclerosis -  macro/microscopical comparisons.  Text
Amyotrophic lateral sclerosis or motor neuron disease -  macroscopical PM specimens, scanned microscopical slides Same, microscopy. Text Chronic subdural hematoma (incidental autopsy finding)
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
...
General and Special Pathology Neuropathology and Neuroimaging Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histological methods
.....