Pathology  -  Neuropathology   -   Neuroimaging
New  additions  (2017,  2018)
..
Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016 2017, 2018 2019, 2020
...
Updated 5/1/2020
General and Special Pathology 
e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese New additions Histopathological  staining  methods
..........
22/11/18
New Cases of Neuroimaging & Neuropathology:
M. 5 yr 5 m.   Desmoplastic medulloblastoma  with rhabdomyoblastic differentiation (medullomyoblastoma)   CT, MRI Same,  macro Same  HE, reticulin. Text Same  IH - desmin, 1A4
Same, GFAP, vimentin, S-100 Same, synaptophysin, chromogranin, MAP2 Same, CD56, INI-1, Ki67, p53
M. 8 yr 10 m Pleomorphic
xanthoastrocytoma.  MRI
Same,  macro Same,  HE, Masson Same,  IH  - GFAP, vimentin,  synaptophysin,  CD34, Ki67, p53 
M. 3 yr 9 m.  Clear cell meningioma of cauda equina. MRI. Same, HE, Masson, reticulin Same, IH - EMA, S-100 Ki67, p53.  Text
F. 3 yr. Tuberculoma of thalamus. MRI Same, macro.  Same, HE Same, Ziehl-Neelsen
M. 5 yr 5 m  Mature teratoma of pineal. MRI Same,  macro Same, HE Same, Masson
F. 44 yr.   Cerebral neuroenteric cyst. MRI Same, HE Same, IH - AE1AE3, CK7, CK20, EMA, GFAP, vimentin.  Text
........
9/9/18
New Cases of Neuroimaging & Neuropathology:
M. 5 yr 2 m.   Melanotic medulloblastoma of cerebellar vermis Original MRI Same,  2 1/2 months after surgery and radiotherapy.  Extensive local recurrence and leptomeningeal spread Same, HE, text Same, IH - GFAP, VIM, S-100, HMB-45
Same, IH - SNF, NF, CD34,  Ki67 F.  7 m.  Atypical teratoid/rhabdoid tumor of cerebellar vermis Same, HE. Text ATRT
Same, IH - GFAP, VIM,  Same, IH - EMA  Same, IH -  AE1AE3 Same, IH -  1A4
Same, IH - SNF, NF Same, IH - INI-1, CD34, Ki67
F. 7 yr  6 m.   Temporo-occipital dysembryoplastic neuroepithelial tumor (DNT)  Same, HE Same, IH - GFAP, VIM, synaptophysin, chromogranin, NF, CD34, Ki67. Pictured - 'floating neuron'
F. 3 yr 4 m.  Malignant rhabdoid tumor of kidney. CT, MRI Same, HE Same,  IH - vimentin, cytokeratins Same, IH - EMA, HHF35
Same, IH - INI-1, Ki67.  Text - Malignant rhabdoid tumor of kidney F. 4 yr 3 m. Same case - 
cerebral metastasis one year after complete clearing of systemic  lesions by chemotherapy
Same, HE
Same,  IH - VIM, AE1AE3 Same,  IH -  EMA, Same,  IH -  1A4 Same,  IH -  S-100, CD56
Same,  IH -  NF Same,  IH - INI1, CD34, Ki67, p53
M. 17 yr 2 m.  Recurrent cerebral metastases of yolk sac tumor of testis.  Third lesion at same site within one year Same, HE. Pictured - Schiller-Duval body  Same,  IH  - AE1AE3,  a-FP,  VIM Same,  IH  - CD34, Ki67, p53, INI-1
.........
7/7/18
New Cases of Neuroimaging & Neuropathology:
F. 8 yr 5 m.   Rosai-Dorfman disease of brain (non-Langerhans histiocytosis). CT, MRI Same,  HE.  Text.  Pictured - emperipolesis Same,  IH - S100, CD45, CD3, CD20, CD68, CD1A Same,  IH - GFAP, SNF, NF,  CD34, Ki67
F. 4 yr 1 m. 
Anaplastic ganglioglioma of thalamus (grade III) evolving to grade I after radio- and chemotherapy
Same, comparison of two samples 10 months apart (before and after treatment); HE of first sample Same, IH of first sample - GFAP, VIM, SNF, NF, CD34, Ki67, p53 Same, HE of second sample
Same, IH of second sample - GFAP, VIM, SNF, NF, CD34, Ki67, p53 F. 11 yr 1 m. Ganglioglioma of deep cerebral white matter. 
CT, MRI
Same, HE, IH.  - SNF, NF, GFAP, VIM,  CD34, Ki67
M. 6 yr 3 m. Ganglioglioma of cervicothoracic spinal cord  Same, HE Same, IH - SNF, NF, GFAP,  CD34, Ki67. Comment
M. 3 yr 1 m. Choroid plexus carcinoma of right lateral ventricle. CT, MRI Same, HE, reticulin Same, IH - AE1AE3, GFAP, VIM, S-100. Same, IH - SNF, CD34, Ki67, p53
F. 3 yr.  Choroid plexus carcinoma of right lateral ventricle  before and after chemotherapy. CT, MRI Same, post treatment specimen - macro, HE  Same, Masson, IH - AE1AE3, vimentin Same, IH - GFAP, EMA, CD56, CD34,  Ki67, p53
......
14/5/18
New Cases of Neuroimaging & Neuropathology:
M. 16 yr.  Yolk sac tumor of testis with two brain metastases at different times Same, primary tumor in testis,  HE, immunohistochemistry. Pictured - Schiller-Duval corpuscle. 
Text.  Alpha-fetoprotein
First brain metastasis, HE, IH. Second brain metastasis, HE, IH.  Pictured - hyaline droplets
M. 7 m. 28 d. Desmoplastic infantile  ganglioglioma (DIG).  Same, macro, HE  Same, special stains. Text. Desmoplastic infantile ganglioglioma and astrocytoma  Same, IH
M. 19 yr. Embryonal carcinoma originating in immature teratoma of testis.  Two brain metastases at different times  Same,  primary tumor in testis and lymph node metastasis (both immature teratoma).  HE. Texts:  mature and immature teratomas,
mixed germinal tumors 
Same, two metachronous brain metastases of embryonal carcinoma. HE.  Text - embryonal carcinoma  Same, first brain metastasis, IH.  Text - CD30
F. 6 yr. 8 m.  Classical medulloblastoma in fourth ventricle;  retrograde seeding of third ventricle mimicking germinoma Same, HE Same, IH
..
20/3/18
New Cases of Neuroimaging & Neuropathology: 
M. 9 yr 6 m. 
Classical medulloblastoma in cerebellar vermis, rich in nuclear palisading and Homer Wright pseudorosettes 
Same, HE Same, temporal lobe metastasis after 8 years, no recurrence at primary site Same, metastasis, HE, faithfully recapitulating primary tumor
Same, temporal cortex infiltration (perineuronal satellitosis) M. 15 yr.  Germinal cell tumor of III ventricle (germinoma in small biopsy) Same, HE, IH - PLAP, c-Kit, OCT4, GFAP, VIM, AE1AE3, Ki67, p53
M. 5 yr 3 m. Primitive neuroectodermal tumor (PNET) of temporal lobe Same, tumor: macro specimen, HE, IH - GFAP,  VIM, CD56,  CD34, Ki67, p53 Same, infiltrated temporal cortex. HE, IH - GFAP, NF, p53
F. 5 yr. Classical medulloblastoma in cerebellar vermis Same, HE, IH - GFAP,  SNF Same, aged 14 years. Recurrence at primary site after 9 years : small  foci of high signal intensity in diffusion sequence, 
progression via III ventricle and foramina of Monro to  large  frontal lobe metastasis
Same, frontal lobe recurrence, HE, Masson, reticulin  Same, IH - GFAP,  VIM, SNF, Ki67  
.......
15/1/18
New Cases of Neuroimaging & Neuropathology:
M. 2 m 12 d Medulloblastoma with extensive nodularity Same, HE, reticulin, Text Same, GFAP, VIM Same, SNF,  MAP2,  CD56
Same, CD34, Ki67 F. 1 yr 1 m  Sacrococcygeal teratoma with yolk sac tumor (or endodermal sinus tumor) component Same, HE, PAS, texts, (sacrococcygeal teratoma
yolk sac tumor)
Same, IH - alpha-fetoprotein, AE1AE3, VIM, Ki67
M. 1 yr 3 m.  Diffuse multicystic ganglioglioma in cerebellum  Same, Macro,  HE Same, GFAP Same, VIM
Same, SNF Same, MAP2.  Arrow - tumor infiltrating cerebellar pia mater  Same, NF, CD34,  Ki67
F. 10 yr 4 m Cerebellar ganglioglioma with pilocytic glial component  +  NF1 Same, Macro, HE Same,  IH - GFAP, VIM, SNF, MAP2, tubulin, CD34, Ki67 
M. 10 yr 2 m.  Ectopic subcutaneous myxopapillary ependymoma of sacral region Same, Macro,  HE Same, Masson, reticulin, Alcian blue, PAS Same, IH - EMA, GFAP, VIM, S-100, AE1AE3, Ki67
M. 12 yr.  Giant cell reparative granuloma of mastoid  Same, Macro, HE, Masson, Reticulin, text Same, IH - CD68, VIM, 1A4, CD34, Ki67, text (myofibroblasts)
..
30/9/17 
New Cases of Neuroimaging & Neuropathology:
F. 1yr 1m. Anaplastic ganglioglioma  in III ventricle. Original biopsy and after 6 months of chemotherapy Same, 1st sample, HE Same, 1st sample, IH - GFAP, VIM, SNF, NF, SMI32, CD34, Ki67 Same, 2nd sample, HE
Same, 2nd sample, IH - GFAP, SNF, NF, SMI32, CD34, Ki67 M. 19 yr. Diffuse low grade astrocytoma of thoracic spinal cord.  Spread to cauda equina and frontal metastasis Same, HE, IH - GFAP, Ki67
MRIs in detail
F. 1yr 3m. Extensive thoracic myxopapillary ependymoma  Same, HE, text Same, Masson's trichrome, Alcian blue Same, IH - GFAP, VIM, S100, CD34, Ki67
M. 6 yr.  Langerhans cell histiocytosis (histiocytosis X or eosinophil granuloma) of skull (occipital bone) Same, HE, IH - CD1A, S100, CD68, CD20, CD3, Ki67 F. 2yr 9m. Langerhans cell histiocytosis  in vertebral body of C7 Same, HE, IH - CD1A, S100, CD68, Ki67
F. 14 yr.  Colloid cyst of III ventricle Same, gross specimen, HE, Masson's trichrome Same,  IH - AE1AE3,  34bE12, 35bH11, CK7, EMA, CD68, VIM, Ki67 
M. 55 yr.  Colloid cyst of III ventricle Same, HE Same, IH -  AE1AE3,  34bE12, CK7, CK20, CD68, Ki67 
F. 22 yr.  Colloid cyst of III ventricle  Same, HE, Masson's trichrome, IH - AE1AE3,  34bE12, EMA,  Ki67 M. 2yr. 8m. 
Anaplastic ganglioglioma of brain stem revisited. Neoplastic seeding of peritoneum via CSF drainage catheter after 4 months.  HE, IH - GFAP, CD20, CD3, CD68, Ki67. Atypical cells in ascitic fluid
......
13/6/17
New Cases of Neuroimaging & Neuropathology:
M. 7 yr. 8 m. Cerebral meningioangiomatosis    MRI, CT Same, surgical pictures, macro specimen  Same, HE, text Same, Masson's trichrome, reticulin
Same, LFB-Nissl Same, IH - neuronal antigens - MAP2, NeuN, SMI32 Same, IH - GFAP, VIM Same, IH - CD34, Ki67
M. 10 m. Choroid plexus papilloma of lateral ventricle  Same, macro, text - choroid plexus tumors Same, HE Same, HE, cerebral infiltration
Same,  IH -  GFAP, VIM, S-100, AE1AE3 Same, IH - synaptophysin, chromogranin, CD56 Same, IH - CD34, Ki-67, p53
F. 3 m. 15 d.  to  3 yr. 4 m.

Anaplastic congenital glioma with spontaneous maturation and regression.  3-year follow-up

Case  summary
 

Same,  CTs, MRIs at various times
Same, 1st biopsy, HE Same, IH - GFAP, VIM Same, IH - SMI-32, chromogranin, synaptophysin  Same, IH - CD34, Ki-67, p53
Same, 2nd biopsy, HE Same, IH - GFAP, VIM Same, IH - SMI-32, chromogranin, synaptophysin, NF Same, IH - CD34, Ki-67, p53
F. 2 yr 9 m.  Embryonal tumor with abundant neuropil and multilayered rosettes.  Recurrence after 6 months.  MRI Same, HE Same, Masson's trichrome, reticulin
Same case, original tumor 

CT, MRI
HE, IH, EM

Same, IH - neuronal antigens  - chromogranin, SMI-32, NF, synaptophysin, NeuN Same, IH  - glial antigens  - GFAP, VIM Same, IH - CD34, Ki-67, p53
.....
20/1/17
New Cases of Neuroimaging & Neuropathology: 
M. 2 yr. 4 m.  Anaplastic ganglioglioma of brain stem. MRI Same, HE, text Same, Masson's trichrome, reticulin  Same, immunohistochemistry  for GFAP, VIM
Same, IH - neuronal antigens, CD34, Ki67 Same, arachnoid cyst 
(incidental finding)
M. 18 yr.  Dermoid cyst of posterior fossa insinuating into foramen magnum and compressing medulla. CT, MRI Same, gross specimen Same, HE
F. 79 yr. Gangliocytoma of pituitary.  CT, MRI Same, HE, text Same, Masson's trichrome, reticulin Same, IH - MAP2, SMI-32, NF
Same, IH - GFAP, AE1AE3, GH, CD34, Ki67 F. 47 yr.  Cysticercus racemosus of brain. CT Same, HE
F. 46 yr.  Progressive multifocal leukoencephalopathy (PML). MRI Same,  HE, LFB-Nissl Same, IH - GFAP, S-100 Same, IH - CD68, CD3, CD20
Same, IH - Ki67, p53 Same patient has low-grade B cell lymphoma. CT - splenomegaly  Same,  bone marrow biopsy - scattered paratrabecular B-lymphocyte  aggregates 
M. 46 yr. Eosinophil pituitary adenoma causing acromegaly.  Negative IH for HGH in spite of increased serum levels. CT, MRI Same, gross specimen Same, HE Same, IH - GH (text), prolactin, AE1AE3,  Ki67. Pictured - GH positive cells from remaining pituitary, GH negative adenoma 
Same, electron microscopy.  Text - secretory granules.    F. 2 yr.  2 m. Embryonal tumor with abundant neuropil and multilayered rosettes.
Revisited for addition of electron microscopy
.
Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016 2017, 2018 2019, 2020
...
Updated 5/1/2020
General and Special Pathology 
e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese New additions Histopathological  staining  methods
......