Pathology  -  Neuropathology   -   Neuroimaging
Additions  posted  2013 - 2014
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
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Updated 27/12/15
General and Special Pathology 
e-mails : gradanat@fcm.unicamp.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histopathological  staining  methods
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30/12/14
New Cases of Neuroimaging & Neuropathology:
Solitary fibrous tumor  and hemangiopericytoma
Illustrated linked text
M. 55 yr.   Occipital epidural solitary fibrous tumor penetrating through bone. CT, MRI  Same, HE, special stains Same, IH 
M. 52 yr.   Occipital / cervical intra- and extracranial solitary fibrous tumor. 10 year follow up and late metastases to thoracic vertebrae. CT, MRI - highlights. Exams in full Same, 2014 sample, HE, special stains Same, 2014 sample, IH Same, 2009 sample, HE
M. 47 yr.  Temporal arterio-venous malformation. Digital angiography Same, specimen, HE Same, special stains
F. 42 yr.   Intraventricular Cysticercus cellulosae. MRI Same, specimen, HE  F. 31 yr. Chondroma of skull base Same, HE, IH
F. 60 yr.  Glioblastoma multiforme of midbrain and pineal region Same, HE, smear, frozen and paraffin sections Same, IH
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29/10/14
Neuro Image Bank

Anatomy of skull. 

Series of 11 axial sections of intact head, brain in situ, injected arteries

New Cases of Neuroimaging & Neuropathology:
F. 1 yr 8 m.  Herpes simplex encephalitis, acute phase Same, HE, LFB-Nissl Same, immunohistochemistry for neural antigens Same, IH for inflammatory cells 
M. 59 yr.  Acute herpetic encephalitis F. 71 yr.  Acute herpetic encephalitis M. 25 yr.  Acute herpetic encephalitis M. 44 yr.  Acute herpetic encephalitis
M. 58 yr.  Herpetic encephalitis - acute and subacute phases, the latter with cortical hemorrhage  F. 35 yr.  Herpetic encephalitis - subacute phase with cortical hemorrhage  F. 20 yr.  Herpetic encephalitis. Late  sequelae after 10 years M. 37 yr. Herpetic encephalitis. Late  sequelae with atrophy and cavitation of left temporal lobe
M. 23 yr.  Herpetic encephalitis. Late  sequelae with atrophy and cavitation of right temporal lobe  M. 27 yr.  Herpetic encephalitis. Late  sequelae with symmetrical atrophy and cavitation of temporal lobes 
M. 47 yr. 
Paracoccidioidomycosis. Multiple nodular cerebral lesions with peripheral contrast enhancement mimicking metastases
Same, specimen, HE Same, special stains, Grocott, PAS
F. 10 yr.  Choroid plexus carcinoma Same, HE, special stains Same, IH
F. 67 yr. Hemangiopericytoma of sellar region mimicking pituitary adenoma  Same, HE, special stains Same, IH
M. 14 yr. Germinoma of hypothalamic region and III ventricle Same, HE, special stains Same, IH
F. 54 yr. Metastatic  melanoma in head of caudate nucleus, with peritumoral and intraventricular hemorrhage Same, HE. Pictured - infiltration of Virchow-Robin spaces by melanoma cells Same, IH. Texts : 
melan Acannibalism among neoplastic cells
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22/8/14
New Cases of Neuroimaging & Neuropathology:
F. 36 yr.  Primitive neuroectodermal tumor (PNET) of brainstem at IV ventricle floor Same, HE Same, immunohistochemistry
M. 8 yr. Pilomyxoid astrocytoma at septum pellucidum  Same, HE,  solid component Same, HE, cyst wall
Leukodystrophies - 
Illustrated linked text  (in Portuguese)
M. 43 yr. Leukodystrophy with spongiform changes of white matter reminiscent of Canavan's disease Same, HE, LFB-Nissl Same, IH
F. 51 yr.  Sarcoidosis of falx and dura mater of cerebral convexity Same, HE, Masson's trichrome M. 38 yr. Small temporal chordoid meningioma  Same, HE, IH. Pictured  - incipient whorl formation
M. 56 yr.  Granular cell tumor of neurohypophysis at III ventricle floor  Same,  HE, special stains, IH
M.  6 yr. Adrenoleukodystrophy M.  11 yr. Adrenoleukodystrophy M.  10 yr. Adrenoleukodystrophy M.  7 yr. Metachromatic leukodystrophy
Leukodystrophies - Illustrated linked text  (in Portuguese)
F.  30  yr. Probable metachromatic leukodystrophy, adult form F.  56 yr. Probable metachromatic leukodystrophy, adult form M.  5 yr. Leukodystrophy associated with congenital muscular dystrophy due to merosin deficiency. Muscle biopsy M.  11 yr.    van der Knaap's disease  (megalencephalic leukoencephalopathy with subcortical cysts). 11-year follow-up. Selection from 4 MRIs. 
Exams in full
Neuro Image Bank
Adrenoleukodystrophy. Massive demyelination of frontal white matter sparing U fibers Metachromatic leukodystrophy. Sulphatide storage in facial nerve nucleus in pons.  Metachromatic leukodystrophy. Sulphatide storage in macrophages in cerebellar white matter  Sudanophilic leukodystrophy. Cavitating demyelination of frontal white matter and ventricular dilatation 
Leukodystrophies - Illustrated linked text  (in Portuguese)
Sudanophilic leukodystrophy. Demyelination of temporal white matter sparing U fibers Krabbe's globoid cell leukodystrophy  - 3 cases.   Demyelination of occipital white matter sparing U fibers Krabbe's globoid cell leukodystrophy. Globoid cells (macrophages) in cerebellar white matter Pelizaeus - Merzbacher's leukodystrophy.  Tigroid appearance of cerebral white matter
Alexander's leukodystrophy. Megalencephaly; softened friable hemispheric white matter  Alexander's leukodystrophy. Abundant Rosenthal fibers in lumbar spinal cord Canavan's leukodystrophy. Spongy degeneration of hemispheric white matter M.  5 yr.   Merosin deficient congenital muscular dystrophy and  leukodystrophy. Muscle biopsy. Brain MRI
F. 81 yr.  Senile plaques at hippocampus.  HE, special stains Same, Congo red and polarized light Same, IH Lhermitte-Duclos disease (dysplastic gangliocytoma of cerebellum).  Text
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10/6/14  -  Neuro Image Bank
Atlas of Macroscopic
Neuroanatomy for Pathologists

Alphabetical index of structures with links to pictures (in Portuguese)

Normal adult brain, external appearance  Cerebral arteries and circle of Willis Cranial nerves
Cerebellum and brain stem in axial sections  Adult brain in axial sections  Single axial section, another specimen Adult brain in coronal sections
Adult brain, midline structures Adult brain in paragittal sections Brain of normal newborn at term Brain of premature infant
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22/4/14
New Cases of Neuroimaging & Neuropathology:
M. 19 yr.  Primary sarcoma of cerebral cortex  Same, scanned slides, HE Same, special stains Same, immunohistochemistry for GFAP, vimentin, S100
Same, IH for synaptophysin, NF, chromogranin, NeuN Same, IH for tubulin, MAP2, CD56 Same, IH for 1A4, HHF35 Same, IH for CD34, Ki67, p53
Same, electron microscopy. Pictured - cytoplasmic filaments reminiscent of myofibrils and sarcomeres in tumor cells M. 20 yr.  Aneurysmal bone cyst of skull and spontaneous (non traumatic) epidural hematoma Same, HE 
F. 52 yr.  Central neurocytoma incarcerating the choroid plexus Same, HE, Masson's trichrome, IH for synaptophysin, Ki67 M. 33 yr.  Old case of central neurocytoma revisited. Electron microscopy. Pictured - Homer Wright pseudorosette  F. 26 yr.  Old case of central neurocytoma revisited. Electron microscopy. Pictured - axon terminal replete with synaptic vesicles
F. 38 yr.  Peripheral primitive neuroectodermal tumor (pPNET) of sacral plexus and sciatic nerve Same, gross specimen, HE Same, Masson's trichrome. Pictured - desmoplastic reaction Same, IH
Same, electron microscopy
Neuro  Image  Bank
Motor cerebral cortex, HE. Pictured - giant pyramidal neurons of Betz Visual cerebral cortex, HE. Pictured - granular neurons and columns of afferent axons Cerebral cortex, LFB - Nissl Cerebral cortex, IH for MAP2
Cerebral cortex, IH for  NeuN Cerebral cortex, IH for  GFAP Cerebral cortex, IH for  VIM Cerebral cortex, electron microscopy
Normal human median nerve.  HE, Masson's trichrome, IH for neurofilament and S100 Normal small nerve of ocular conjunctiva, electron microscopy Normal human skeletal muscle, electron microscopy
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31/12/13
New Cases of Neuroimaging & Neuropathology:
F. 72 yr. Creutzfeldt-Jakob disease (spongiform encephalopathy). Text : diffusion-weighted MRI in early diagnosis of CJD Same, brain specimen. Text : autopsy protocol in CJD  Same, HE - basal ganglia, hippocampus Same, HE - frontal cortex, cerebellum, pons
Same, gliosis of  caudate nucleus. Immunohistochemistry for GFAP, vimentin.  M. 38 yr.  Circumscribed tuberculous meningitis in HIV + patient Same, HE, Ziehl
M. 36 yr.  Granular cell tumor of neurohypophysis Same, HE, special stains Same, IH. Text Same, EM 
M. 52 yr.  Hemangioblastoma of medulla oblongata Same, specimen, HE, special stains  Same, IH. Texts : NSE, inhibin Same, electron microscopy. Text
F. 32 yr.  Chordoma of clivus Same, HE, special stains Same, IH
F. 1 yr. 6 m.  Intraspinal dermoid cyst  Same, HE F. 30 yr. Microcystic meningioma of greater sphenoid wing, causing hyperostosis Same, HE
F. 44 yr. Intraspinal psammomatous meningioma  Same, HE, special stains Same, IH
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30/10/13
New Cases of Neuroimaging & Neuropathology:
M. 4 m.  Occipital encephalocele  Same, specimen, scanned slides Same, HE. Pictured : interface between skin and atrophic brain gyri  Same, polymicrogyria, persistent fetal meningeal vascularization. Text
Same, ependyma of lateral ventricle, cerebellar cortex, heterotopic glial nodules in leptomeninges. Text : encephaloceles M. 16 yr.  Cystic, partially ossified chondroma of brain convexity with dural attachment  Same, specimen, HE, IH. Text
F. 27 yr.  Pseudotumoral toxoplasmosis in right parietal lobe Same, smear, frozen and paraffin sections F. 77 yr.  Clear cell ependymoma of cervical spinal cord Same, HE. Text
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27/9/13
New Cases of Neuroimaging & Neuropathology: 
M. 34 yr.  Cryptococcoma of right parietal lobe Same, specimen, scanned slides, HE Same, special stains on paraffin sections Same, special stains on smears of the fixative containing fungi in suspension
Same, electron microscopy. Texts : cell wall, capsule M. 5 mths.  Choroid plexus cyst of left lateral ventricle  Same, specimen, stereoscopical images, scanned slides, HE. Text
F. 5 yr.   Pilomyxoid astrocytoma Same, HE.  Same, IH. Text
F. 14 yr.   Pilocytic astrocytoma of quadrigeminal plate with CSF seeding of lumbosacral cul-de-sac Same, HE, Masson's trichrome Same, IH
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13/7/13
New Cases of Neuroimaging & Neuropathology:
M. 19 yr.  Chondromyxoid fibroma  of occipital bone; intra-  and extracranial extension Same, macro specimen, HE, text Same, special stains Same, immunohistochemistry for VIM, 1A4, HHF-35
Same, IH for CD56,  S100,  CD34,  Ki67,  p53 Same, electron microscopy. Texts : fibronectin, integrins
M.  6 m. Choroid plexus papilloma of lateral ventricle Same, macro specimen, stereoscopical images, HE, special stains Same, IH 
M. 29 yr.  Anaplastic astrocytoma  of lumbar spinal cord Same, HE, IH M. 52 yr. Pineocytoma Same, HE, IH
Multifocal glioblastoma multiforme  - 12 cases.   SummaryText
M. 67 yr.  Multifocal glioblastoma multiforme
6 foci
M. 73 yr.  4 foci F. 75 yr.  4 foci M. 49 yr.  4 foci
M. 55 yr.  3 foci M. 59 yr.  3 foci  F. 70 yr.  3 foci F. 71 yr.  2 foci
M. 55 yr.  2 foci M. 48 yr.  2 foci M. 55 yr.  2 foci F. 56 yr.  2 foci
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31/5/13
New Cases of Neuroimaging & Neuropathology: 
F. 48 yr.  Right temporal gliosarcoma.  Original MRI Same, recurrence 4 months after surgery First specimen,  glioblastoma component. HE Same, special stains. Reticulin fibers limited to thickened vessels, absent among tumor cells
Same, immunohistochemistry. Glioblastoma cells positive for GFAP, sarcomatous cells negative Same, second specimen, after 4 months - gliosarcoma component only. HE Same, special stains. Collagen fibers surround individual tumor cells Same, IH
Same, electron microscopy - extracellular matrix with collagen fibrils separate  neoplastic cells  F. 48 yr.  Chordoid meningioma of olfactory groove invading nasal cavity. CT Same, MRI
Same, HE Same,  special stains Same, IH  Same, EM
F. 48 yr.  Single demyelinating lesion of right parieto-occipital region Same, MRI after 5 months Same, HE, LFB-Nissl Same, IH - GFAP, VIM, NF
Same, IH for lymphocytes, macrophages, Ki-67 F. 62 yr.  Amyloid angiopathy and brain hemorrhage Same, HE, Masson's trichrome. Leptomeningeal vessels with amyloid deposition Same, Congo red and polarized light. Text
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26/2/13
New Cases of Neuroimaging & Neuropathology: 
M. 27 yr.  Occipital aneurysmal bone cyst Same, gross specimen, scanned slides. Text Same, HE -  membranous septa Same, HE - new bone deposition at septa
F. 56 yr.  Psammomatous meningioma of olfactory groove  Same, HE F. 16 yr.  Aneurysmal bone cyst of thoracic spine
F. 17 yr.  Skull base chondroblastoma (temporal bone) Same, HE - pictured - chondroblasts among chicken wire like calcifications. Text Same, immunohistochemistry
F. 64 yr.  Glioblastoma multiforme of pineal  Same, HE. Text Same, IH
F. 52 yr.  B cell lymphoma of dura mater, occipital bone and soft tissues  Same, HE, IH M. 61 yr. Skull base plasmacytoma (occipital and temporal bones) Same, HE, IH
..
Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
...
General and Special Pathology Neuropathology and Neuroimaging Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histopathological  staining  methods
.....