Pathology  -  Neuropathology   -   Neuroimaging
Additions  posted  2011 - 2012
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
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Updated 27/12/15
General and Special Pathology 
e-mails : gradanat@fcm.unicamp.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histopathological  staining  methods
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20/12/12
New Cases of Neuroimaging & Neuropathology: 
F. 20 yr.  Dysembryoplastic neuroepithelial tumor   (DNT) of right superior frontal gyrus. MRI, surgical field pictures, specimen Same, HE. Text Same, Masson's trichrome Same, luxol fast blue - cresyl violet
Same, IH for neurons - MAP2 Same, IH for neurons - NF, tubulin Same, IH for astrocytes - GFAP, VIM, S-100 Same, IH  - CD34, Ki67
M. 13 yr. DNT of left pre-central gyrus  Same, HE - pictured :  perineuronal satellitosis M. 24 yr. DNT of left cingulate gyrus at genu of corpus callosum  M. 9 yr. DNT of antero-medial right temporal lobe
F. 8 yr.  DNT of basal gyri of left temporal lobe F. 7 yr.  DNT of left cuneus M. 29 yr. DNT of isthmus of right cingulate gyrus. 9-year followup F. 30 yr.  DNT of antero-medial left temporal lobe
F. 32 yr.  DNT of right middle frontal gyrus F. 8 yr.  DNT of left middle and inferior temporal gyri
F. 68 yr.  Exophytic meningioma of lesser sphenoid wing with hyperostotic nodule at implantation Same, specimen, HE Same, Masson's trichrome Same, hyperostotic nodule under polarized light
M. 64 yr. Dermoid cyst  (mature teratoma) in cerebellar vermis + posterior fossa arachnoid cyst  Same, specimen, HE
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5/12/12
New Cases of Neuroimaging & Neuropathology: 
F. 64 yr.  Bifrontal desmoplastic ganglioglioma  above the corpus callosum with areas of central neurocytoma  Same,  ganglioglioma component - gross specimen, smear, paraffin HE Same, special stains Same, immunohistochemistry for astrocytes - GFAP, VIM
Case summary
Same, IH for neurons - MAP2, NF Same, IH for neurons - chromogranin, synaptophysin, class III beta tubulin,  NeuN Same, IH - CD34, Ki67, p53 Same, electron microscopy - neurons
Same, EM - dendrites, axons, neuropil, synapses Same, EM - astrocytes, granular bodies, capillary Same,  central neurocytoma component. HE Same, IH for astrocytes - GFAP, VIM
Same, IH for neurons -  NF, chromogranin, synaptophysin Same, IH for neurons - MAP2, NeuN Same, IH, nestin, CD34, Ki67, p53
M. 30 yr. Hemangiopericytoma of tentorium cerebelli Same, HE Same, special stains Same, IH
Same, EM. Pictured - reticulin fibers
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18/9/12
New Cases of Neuroimaging & Neuropathology: 
F. 43 yr.  Supratentorial primitive neuroectodermal tumor (PNET).  MRI 2 ½ months after first operation Same, first sample, HE Same, second sample, HE Same, special stains
Same, immunohistochemistry for GFAP, VIM, nestin Same, IH, tubulin (text), CD56, S-100, NF Same, IH, CD68, HAM-56,  CD3, CD20 Same, IH, CD34, 1A4, Ki67, p53
Same, electron microscopy M. 25 yr.  Ganglioglioma exceptionally rich in eosinophilic granular bodies (EGBs) Same, HE
Same,  special stains Same, IH - synaptophysin, NF. Pictured - binucleated neuron Same, IH - GFAP, VIM Same, IH - CD34, Ki-67. Pictured -'feathery cell'
M. 58 yr. Basilar artery thrombosis in sickle cell disease Same, pontine infarction Same, HE  -  coagulation and  liquefaction necrosis, sickled red blood cells in basis pontis  Same, basilar artery thrombus under stereomicroscope and in HE stain 
Same, spleen, liver, kidney, lung, HE M. 62 yr.  Progressive multifocal leucoencephalopathy   (PML) Same,  HE (needle biopsy). Pictured - atypical astrocytes 
Text (PML) Text - HIV encephalopathy 
M. 25 yr. Progressive multifocal leucoencephalopathy   (PML) affecting cerebellum and brain stem M. 41 yr. Progressive multifocal leucoencephalopathy   (PML) M. 47 yr.  HIV encephalopathy M. 52 yr. HIV encephalopathy
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14/8/12
New Cases of Neuroimaging & Neuropathology: 
M. 54 yr.  Cerebral histoplasmosis. MRI 9/2011. Hydrocephalus, small periventricular  lesions Same, MRI 3/2012. Obliteration of third ventricle  Same, CT 3/2012. Small calcified nodule in right anterior horn of lateral ventricle
Case summarytext
Same, gross brain pathology. Exudative and hemorrhagic lesions in third ventricle Same, HE, third ventricle lesions. Histoplasma capsulatum fungi in macrophage phagosomes Same, HE,  gliotic / fibrotic lesion at anterior commissure  (detected on MRI 6 months previously) Same, HE, necrotic calcified nodule at right anterior horn of lateral ventricle (also visible on MRI 6 months previously)
Same, HE,  fourth ventricle and leptomeningeal lesions - vasculitis, ependymitis, radiculitis Same, Masson's trichrome.  Fibrosis of basal leptomeninges Same, techniques for fungi - Grocott + HE, Grocott + light green, PAS Same, IH for inflammatory cells : CD68, HAM-56, CD3, CD20
Same, IH for nerve tissue : GFAP, NF (pictured - axons among fungi-filled macrophages)  Same, electron microscopy
M. 44 yr. Oncocytoma (null cell adenoma) of  pituitary Same, HE  Same, IH. TSH  detectable in few cells, other hormones negative Same, EM. Tumor cell rich in abnormal mitochondria, rare secretory granules 
New slides for  undergraduate Pathology 
classes
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A. 271a. Gastric intramucous signet ring adenocarcinoma A. 98a. Arteriolar hyaline change  of kidney in benign hypertension A. 98a. Glomerular hyaline change in benign hypertension
A. 72b. Biliary cirrhosis. Bilirubin in dilated intrahepatic bile ducts.  A. 317a. Early  organizing thrombus in femoral vein, recanalized thrombus in artery A. 317a. Same, Masson's trichrome. A 193a. Leiomyosarcoma. Nuclear atypia, mitoses
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3/6/12
New Cases of Neuroimaging & Neuropathology: 
M. 68 yr.  Granular cell astrocytoma of brain. CT, MRIs 2011 Same, MRI, post-operative followup after one year.  Same, HE Same, special stains : Masson's trichrome, PAS
Case summarytext
Same, immunohistochemistry for GFAP Same, IH, VIM, nestin Same, CD34  Same, CD68, HAM-56
Same, S-100, NF, CD99 Same, Ki-67, p53 Same, electron microscopy, glutaraldehyde-fixed Same, EM, from selected paraffin block
M. 59 yr.  Granular cell astrocytoma of brain. HE Same, IH, GFAP, VIM, S-100 Same, IH, CD34, Ki-67, p53
F. 20 yr. Epidural thoracic ganglioneuroblastoma  Same, HE, text Same, IH 
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26/3/12
New Cases of Neuroimaging & Neuropathology: 
F. 37 yr.  Intracranial solitary fibrous tumor developing multiple bone metastases 3 years after craniotomy Same, primary tumor, HE Same, special stains Same, IH
Same, vertebral metastasis at T11 with cord compression 3 years later Same, metastasis, HE, special stains Same, metastasis, IH 
M. 21 yr.  Primary meningeal sarcoma with polyphenotypic antigen expression Same, HE Same, special stains Same, IH, muscle antigens, vimentin
Same, IH, epithelial antigens  Same, IH, neural antigens Same, IH - CD34, Ki-67, p53
M. 51 yr. Secretory meningioma  at cerebello-pontine angle masquerading as  schwannoma on MRI Same, HE, special stains Same, IH 
M. 43 yr. Giant bilateral
fronto-parietal meningioma  with hyperostosis and brain compression (MRI  Feb 2008)
Same, midline section through infiltrated bone, HE.  Excision of intracranial component deferred due to profuse bleeding Same, 4 years later. 
Tumor growth through bone gap and under scalp (MRI Oct 2011)
Same, intracranial tumor specimen weighed 290 g HE 
M. 69 yr. Frontal meningioma  with hyperostosis and bone destruction Same, HE - intraosseous component. Ischemic necrosis of tumor and bone trabeculae Same, HE - intracranial component. Cerebral infiltration
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17/2/12
New Cases of Neuroimaging & Neuropathology: 
F. 58 yr.  Giant cell glioblastoma with a component of conventional glioblastoma multiforme Same, surgical specimen. Encapsulated tumor with necrotic center Same, giant cell part  - HE, Masson's trichrome Same, giant cell part - IH - glial markers, GFAP, VIM, S-100
Same, giant cell part - IH - neuronal markers, synaptophysin, chromogranin, NF, class III beta-tubulin Same, giant cell part - IH - MAP2, CD34, Ki-67, p53 Same, conventional glioblastoma part  - HE  Same, conventional glioblastoma part - IH - glial markers, GFAP, VIM
Same, conventional glioblastoma part - IH - neuronal markers, NF, MAP2, tubulin. Pictured - neoplastic infiltration among axons Same, conventional glioblastoma part - IH - CD34, Ki-67, p53 F. 45 yr. Left parietal ganglioglioma
Same, HE. Pictured - multinucleated tumor cell Same, IH - glial markers, GFAP, VIM Same, IH - neuronal markers, synaptophysin, NF, chromogranin, NeuN Same, IH  - MAP2, tubulin, CD34, Ki-67
M. 12 yr. Small solid ganglioglioma of right insula Same, HE. Pictured - abnormal neuron Same, IH - glial markers, GFAP, VIM Same, IH - neuronal markers, synaptophysin, NF, chromogranin, NeuN
Same, IH -  MAP2, tubulin, CD34, Ki-67 F. 51 yr. Solid-cystic ganglioglioma of right temporal and occipital regions Same, HE, Masson's trichrome. Pictured - multinucleated tumor cell
Same, IH - glial markers, GFAP, VIM Same, IH - neuronal markers, synaptophysin, chromogranin, NF, NeuN Same, IH  - MAP2, tubulin, CD34, Ki-67
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18/12/11
New Cases of Neuroimaging & Neuropathology: 
M. 24 yr. Atypical central neurocytoma  Same, HE, special stains. Pictured : atypical mitosis. Comment. Same, IH neuronal markers. Pictured : synaptophysin-positive perivascular pseudorosettes  Same, IH glial markers, CD34, Ki-67 (> 50%)
M. 28 yr. Subependymal giant cell astrocytoma (SEGA) unassociated with tuberous sclerosis Same, HE - smear, paraffin. Comment. Texts: SEGA, Tuberous sclerosis Same, IH glial markers Same, IH neuronal markers
Same, IH nestin, EMA, CD34, Ki-67 M. 26 yr.  Central neurocytoma  Same, HE, IH
M. 35 yr. Central neurocytoma  Same, HE. Text:  Central neurocytoma Same, IH neuronal markers, CD34 Same, IH glial markers, Ki-67
F. 44 yr.  Ectopic invasive pituitary adenoma centered in sphenoid sinus, spilling into left nasal cavity. Normal sella turcica Same, specimen, HE. Pictured - nuclear atypia. Text : ectopic pituitary adenoma Same, special stains. Pictured : mucus filled nasal glands trapped within the adenoma Same, IH. Pictured : positivity for growth hormone in adenoma cells
F. 54 yr. Cerebro-spinal sarcoidosis Same, HE, special stains. Text : systemic and CNS sarcoidosis Same, IH
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11/11/11
New Cases of Neuroimaging & Neuropathology: 
M. 48 yr.  Primary necrotizing vasculitis of central nervous system Same, in situ view at surgery, HE Same, special stains Text : primary angiitis of brain
M. 16 yr. Left frontal cavernoma, first bleeding. Case summary, CT scans  Same, early phase MRI Same, control after one year Same, new bleeding 
(2 years from onset)
Same, surgical specimen under stereomicroscope Same, HE Same, Masson's trichrome Text : vascular malformations of the central nervous system: telangiectasias, cavernomas, AVMs
F. 28 yr. Cavernoma of right cingulate gyrus Same, surgical specimen under stereomicroscope Same, HE, Masson's trichrome
F. 46 yr. Bilateral frontal gliomatosis cerebri involving genu of corpus callosum Same, HE, immunohistochemistry F. 42 yr. Centroencephalic diffuse large B-cell lymphoma  Same, HE, IH
Text : gliomatosis cerebri Text : primary lymphomas of CNS
M. 28 yr. Papillary craniopharyngioma Same, HE Same, Masson's trichrome
......
18/9/11
New Cases of Neuroimaging & Neuropathology: 
F. 52 yr.  Anaplastic parietal ganglioglioma  Same, macro specimen, smear, scanned slides Same, HE Same, IH : glial markers (GFAP, VIM, S-100); nestin
Same, neuronal markers, CD34, Ki67 M. 55 yr. Frontal ganglioglioma with pilocytic glial component Same, HE : smear, paraffin
Same, IH : GFAP, VIM Same, IH : MAP2, chromogranin, NeuN, neurofilament Same, IH : nestin, CD34, Ki67 Text : gangliogliomas
M. 52 yr.  Sinonasal neuroendocrine carcinoma Same, specimen, HE  Same, IH : epithelial markers,  vimentin Same, IH : neural markers
Texts about neuroepithelial tumors of the nasal cavity and paranasal sinuses : olfactory neuroblastoma (1) (2); neuroendocrine carcinoma, sinonasal undifferentiated carcinoma (SNUC).
M. 63 yr. Langerhans cell histiocytosis of orbit Same, HE Same, IH Same, EM
Texts about : macrophages, dendritic cells, Langerhans cells, Birbeck granules, Langerin, histiocytoses, Langerhans cell histiocytosis, CD1a, CD68.
M. 37 yr. Langerhans cell histiocytosis of spinal canal C7-T1, HE Same, IH
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22/8/11
New Cases of Neuroimaging & Neuropathology:
M. 70 yr.  Atypical meningioma with intra and extracranial growth replacing left side of frontal bone  Same, HE - hipercellularity, small cells, prominent nucleoli Same, immunohistochemistry.
Pictured: EMA positivity in tumor cell membranes. 
F. 63 yr. Giant meningioma of olfactory groove Same, HE : nuclear palisading mimicking schwannoma F. 57 yr. Meningioma en plaque of middle fossa infiltrating cavernous sinus and middle ear Same, HE : whorls in middle ear biopsy
M. 60 yr. Metastatic melanoma in genu of corpus callosum mimicking butterfly glioma  Same, HE Same, IH. 
Pictured: HMB-45 positivity in isolated tumor cell
Texts: HMB-45, brain metastases
M. 49 yr. Cerebellar abscess by the fungus Paracoccidioides brasiliensis Same, HE - 
double membrane yeasts, multiple budding
Same, Grocott + hematoxylin Same, Grocott + light green, PAS + hematoxylin
M. 71 yr. Cerebellar abscess caused by Paracoccidioides brasiliensis Same, smear : HE, Grocott, Papanicolaou Same, cell block : HE, Grocott
Image bank, inflammations, digestive tract
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Helicobacter pylori in gastric biopsy.   Warthin-Starry silver stain
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11/6/11
New Cases of Neuroimaging & Neuropathology:
M. 38 yr.  Mucormycosis of nasal cavity, orbit and brain Same, HE  Same, special stains : Grocott + hematoxylin, Grocott  + HE Same, Grocott + light green, PAS + hematoxylin
Text: Mucormycosis
M. 63 yr. Paracoccidioidomycoma of cerebellopontine angle  Same, HE. Pictured : Paracoccidioides brasiliensis in giant cells  Same,  plain Grocott, Grocott  + HE Same, Grocott + hematoxylin
Same, plain PAS,
PAS + hematoxylin
F. 44 yr.  Tanycytic ependymoma of  lumbar spinal cord Same, HE
M. 42 yr. Primary extracerebral meningeal glioma Same, HE Same, HE, Perls Same, IH
Text: Primary extracerebral meningeal glioma
Neuro  Image  Bank
»»»
Cerebral chromomycosis (cladosporiosis).  HE Same, Grocott + hematoxylin Same, Grocott + light green, Masson's trichrome 
Text: Chromomycosis
  Inflammation Image  Bank 
Pulmonary cryptococcosis - small subpleural focus. Incidental autopsy finding. HE Same, special stains : mucicarmine, PAS, Grocott + light green Pleural and pulmonary mucormycosis. HE Same, plain Grocott, 
Grocott + hematoxylin
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15/4/11
New Cases of Neuroimaging & Neuropathology:
F. 9 yr. Supratentorial primitive neuroectodermal tumor (PNET) Same, specimen, HE  Same, special stains. Pictured : elastic fibers amid tumor cells Same, immunohistochemistry : GFAP, VIM
Case summary, comment, texts: supratentorial PNETs, elastic fibers, nestin
Same, IH :  nestin, S100, CD56 Same, IH : synaptophysin, chromogranin, NF, EMA Same, IH : AE1AE3,  1A4,  CD34,  Ki-67,  p53 Same, electron microscopy. Pictured : elastic fibers 
F. 71 yr. Extradural spinal leiomyoma  Same, HE, Masson's trichrome, reticulin  Same, IH. Texts: vimentin, intermediate filaments  Same, EM
M. 55 yr. Temporal pilocytic astrocytoma Same, HE. Pictured : protoplasmatic area with eosinophilic granular bodies (EGBs) F. 66 yr. Pilocytic astrocytoma of cerebellar vermis in the 7th decade Same, HE. Pictured : hyalinized vessels
Previously  presented 
case  revisited : 
M.  49yr. Ependymoma at foramen of Luschka  Same, HE. Ependymoma featuring hyaline centered rosettes containing elastic fibers 
Same, special stains. Pictured : grainy elastic fibers in Verhoeff's stain Same, IH Same, EM, general features of ependymoma Same, EM, clumps of elastic fibers at core of 'hyaline rosettes'
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5/2/11  Meningiomas - illustrated teaching texts : general featuresneuroimaging, gross pathology, microscopy, immunohistochemistry, electron microscopy, meningiomas WHO grade I, grade II and grade III.
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
...
General and Special Pathology Neuropathology and Neuroimaging Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histopathological  staining  methods
.....