Pathology  -  Neuropathology   -   Neuroimaging
New  additions  (2015 - 2017)
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015 - 2017
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Updated 30/9/2017
General and Special Pathology 
e-mails : gradanat@fcm.unicamp.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histopathological  staining  methods
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30/9/17 
New Cases of Neuroimaging & Neuropathology:
F. 1yr 1m. Anaplastic ganglioglioma  in III ventricle. Original biopsy and after 6 months of chemotherapy Same, 1st sample, HE Same, 1st sample, IH - GFAP, VIM, SNF, NF, SMI32, CD34, Ki67 Same, 2nd sample, HE
Same, 2nd sample, IH - GFAP, SNF, NF, SMI32, CD34, Ki67 M. 19 yr. Diffuse low grade astrocytoma of thoracic spinal cord.  Spread to cauda equina and frontal metastasis Same, HE, IH - GFAP, Ki67
MRIs in detail
F. 1yr 3m. Extensive thoracic myxopapillary ependymoma  Same, HE, text Same, Masson's trichrome, Alcian blue Same, IH - GFAP, VIM, S100, CD34, Ki67
M. 6 yr.  Langerhans cell histiocytosis (histiocytosis X or eosinophil granuloma) of skull (occipital bone) Same, HE, IH - CD1A, S100, CD68, CD20, CD3, Ki67 F. 2yr 9m. Langerhans cell histiocytosis  in vertebral body of C7 Same, HE, IH - CD1A, S100, CD68, Ki67
F. 14 yr.  Colloid cyst of III ventricle Same, gross specimen, HE, Masson's trichrome Same,  IH - AE1AE3,  34bE12, 35bH11, CK7, EMA, CD68, VIM, Ki67 
M. 55 yr.  Colloid cyst of III ventricle Same, HE Same, IH -  AE1AE3,  34bE12, CK7, CK20, CD68, Ki67 
F. 22 yr.  Colloid cyst of III ventricle  Same, HE, Masson's trichrome, IH - AE1AE3,  34bE12, EMA,  Ki67 M. 2yr. 8m. 
Anaplastic ganglioglioma of brain stem revisited. Neoplastic seeding of peritoneum via CSF drainage catheter after 4 months.  HE, IH - GFAP, CD20, CD3, CD68, Ki67. Atypical cells in ascitic fluid
......
13/6/17
New Cases of Neuroimaging & Neuropathology:
M. 7 yr. 8 m. Cerebral meningioangiomatosis    MRI, CT Same, surgical pictures, macro specimen  Same, HE, text Same, Masson's trichrome, reticulin
Same, LFB-Nissl Same, IH - neuronal antigens - MAP2, NeuN, SMI32 Same, IH - GFAP, VIM Same, IH - CD34, Ki67
M. 10 m. Choroid plexus papilloma of lateral ventricle  Same, macro, text - choroid plexus tumors Same, HE Same, HE, cerebral infiltration
Same,  IH -  GFAP, VIM, S-100, AE1AE3 Same, IH - synaptophysin, chromogranin, CD56 Same, IH - CD34, Ki-67, p53
F. 3 m. 15 d.  to  3 yr. 4 m.

Anaplastic congenital glioma with spontaneous maturation and regression.  3-year follow-up

Case  summary
 

Same,  CTs, MRIs at various times
Same, 1st biopsy, HE Same, IH - GFAP, VIM Same, IH - SMI-32, chromogranin, synaptophysin  Same, IH - CD34, Ki-67, p53
Same, 2nd biopsy, HE  Same, IH - GFAP, VIM Same, IH - SMI-32, chromogranin, synaptophysin, NF Same, IH - CD34, Ki-67, p53
F. 2 yr 9 m.  Embryonal tumor with abundant neuropil and multilayered rosettes.  Recurrence after 6 months.  MRI Same, HE Same, Masson's trichrome, reticulin
Same case, original tumor 

CT, MRI
HE, IH, EM

Same, IH - neuronal antigens  - chromogranin, SMI-32, NF, synaptophysin, NeuN Same, IH  - glial antigens  - GFAP, VIM Same, IH - CD34, Ki-67, p53
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20/1/17
New Cases of Neuroimaging & Neuropathology: 
M. 2 yr. 4 m.  Anaplastic ganglioglioma of brain stem. MRI Same, HE, text Same, Masson's trichrome, reticulin  Same, immunohistochemistry  for GFAP, VIM
Same, IH - neuronal antigens, CD34, Ki67 Same, arachnoid cyst 
(incidental finding)
M. 18 yr.  Dermoid cyst of posterior fossa insinuating into foramen magnum and compressing medulla. CT, MRI Same, gross specimen Same, HE
F. 79 yr. Gangliocytoma of pituitary.  CT, MRI Same, HE, text Same, Masson's trichrome, reticulin Same, IH - MAP2, SMI-32, NF
Same, IH - GFAP, AE1AE3, GH, CD34, Ki67 F. 47 yr.  Cysticercus racemosus of brain. CT Same, HE
F. 46 yr.  Progressive multifocal leukoencephalopathy (PML). MRI Same,  HE, LFB-Nissl Same, IH - GFAP, S-100 Same, IH - CD68, CD3, CD20
Same, IH - Ki67, p53 Same patient has low-grade B cell lymphoma. CT - splenomegaly  Same,  bone marrow biopsy - scattered paratrabecular B-lymphocyte  aggregates 
M. 46 yr. Eosinophil pituitary adenoma causing acromegaly.  Negative IH for HGH in spite of increased serum levels. CT, MRI Same, gross specimen Same, HE Same, IH - GH (text), prolactin, AE1AE3,  Ki67. Pictured - GH positive cells from remaining pituitary, GH negative adenoma 
Same, electron microscopy.  Text - secretory granules.    F. 2 yr.  2 m. Embryonal tumor with abundant neuropil and multilayered rosettes. 
Revisited for addition of electron microscopy
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30/11/16
New Cases of Neuroimaging & Neuropathology:
M. 1 yr. 1 m. Atypical teratoid/rhabdoid tumor of right cerebral hemisphere. CT, MRI Same, HE, text Same, Masson's trichrome, reticulin Same, immunohistochemistry  for epithelial antigens - EMA, AE1AE3
Same, IH - glial antigens  - GFAP, vimentin, S100 Same, IH - neuronal antigens  - synaptophysin, MAP2, SMI-32 Same, IH - 1A4, CD34 Same, IH - INI1, Ki67, p53
Same, IH - CD68, HAM56, CD3, CD20 M. 7 yr. 2 m. Glioblastoma multiforme of thalamus, CT, MRI Same, HE, text
M. 18 yr. Dysembryoplastic neuroepithelial tumor (DNT) of right inferior temporal / occipital gyri. CT, MRI Same, HE Same, LFB-Nissl Same, IH - GFAP
Same, IH - MAP2 Same, IH - NeuN Same,  IH - SMI32, NF Same,  IH - synaptophysin, chromogranin, CD34, Ki67
M. 20 yr.  Brain and lung metastases of testicular choriocarcinoma.  CT, MRI Same, contralateral brain metastases after one year. MRI Same, immature teratoma of testis associated with choriocarcinoma, HE  Same, primary choriocarcinoma in testis, HE
Same, choriocarcinoma, first brain metastasis. HE, IH  Same, choriocarcinoma, second brain metastasis. Macro, HE 
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31/8/16
New Cases of Neuroimaging & Neuropathology:
F. 2 yr.  2 m. Embryonal tumor with abundant neuropil and multilayered rosettes. CT, MRI Same, specimen, HE, text Same, immunohistochemistry for glial antigens  - GFAP, vimentin Same, immunohistochemistry for neuronal antigens - neurofilament, synaptophysin, MAP2, NeuN
Same, IH for EMA, Ki67 F. 4 yr.  Diffuse anaplastic astrocytoma of pons.  MRI Same, HE
F. 8 yr.  Ganglioglioma with pilocytic astrocytoma component in spinal cord, MRI Same, HE Same, IH for glial antigens  - GFAP, vimentin Same, IH for neuronal antigens -  chromogranin, MAP2, SMI-32
Same, IH for CD34, Ki67 M. 11 yr.  Glioblastoma multiforme of pons.  MRI Same, HE, GFAP, Ki67
M. 23 yr. Cystic ganglioglioma with minute solid component of pilocytic astrocytoma in cingulate gyrus. MRI Same, HE Same,  IH - GFAP, chromogranin, CD34, Ki67
F. 72 yr. Cerebral amyloid angiopathy, parenchymatous and ventricular hemorrhage Same, HE, Congo red Same, Congo red under polarized light
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20/7/16
New Cases of Neuroimaging & Neuropathology: 
F. 1 yr. 5 m.   Hemimegalencephaly, agyria, pachygyria. MRI Same, gross specimen Same, HE Same, LFB-Nissl
Same, immunohistochemistry for GFAP Same, vimentin Same, MAP2 Same, NeuN
Texts. 

Agyria, pachygyria, hemimegalencephaly, meningeal glial heterotopia

Same, SMI-32 Same, CD34, Ki-67 F. 72 yr. Cerebellar liponeurocytoma , HE, texts : liponeurocytoma, rhythmic nuclear palisading
M. 20 yr. Ganglioglioma of head of caudate nucleus Same,  hypoplasia of vermis and cerebellar hemispheres Same, HE, special stains Same, IH for GFAP, VIM
Same, MAP2, NeuN Same, SMI-32, chromogranin, synaptophysin Same, CD34, Ki67
M. 15 yr.  Atypical central neurocytoma of third ventricle Same, HE, IH for glial antigens Same, IH for neuronal antigens, CD34, Ki67
F. 24 yr.  Desmoplastic medulloblastoma  Same, HE, reticulin Same, IH, text: medulloblastomas
Neuro Image Bank.    NNormal sympathetic ganglion 
HE Masson's trichrome, neurons Same, sympathetic nerves Reticulin
PAS  LFB-Nissl MAP2 NF
SMI-32 Synaptophysin Chromogranin S-100
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5/5/16
New Cases of Neuroimaging & Neuropathology: 
M. 4 yr. 4 m.  Subependymal giant cell astrocytoma in tuberous sclerosis. MRI Same, multiple tubers in cerebral hemispheres Same, subependymal giant cell astrocytoma. HE, Masson's trichrome, reticulin silver stain Same, immunohistochemistry for GFAP, VIM 
Same, S-100, HAM 56, CD68 Same, NF, chromogranin, MAP2, CD56 Same, EMA, CD34, Ki67
M. 1 yr. 9 m. Tuberous sclerosis. Giant partly calcified fronto-parietal tuber, CT, MRI  Same, surgical specimen Same, HE, Masson's, reticulin Same, LFB-Nissl
Same, GFAP, VIM Same,  MAP2, chromogranin Same, SNF, NF, SMI-32. Text Same, CD34, Ki67
M. 23 yr. Frontal giant cell glioblastoma Same, surgical specimen Same,  HE Same, Masson's, reticulin
Same, GFAP, VIM Same, S-100, CD56, NF Same, CD34, Ki67
M. 25 yr.   Neurofibromatosis type 2. Ependymomas in medulla and lumbar spinal cord. CT, MRI Same, bilateral vestibular and right oculomotor schwannomas Same, meningioma of optic nerve sheath, others Same, surgical field and specimen
Same,  HE Same,  IH - GFAP, VIM, EMA, NF, CD34, Ki-67
F. 55 yr. Fibroblastic S-100 positive meningiomas of posterior fossa raising schwannoma as differential diagnosis Same, HE,  IH - EMA, S-100 M. 74 yr. Fibroblastic S-100 positive meningioma of posterior fossa at internal auditory canal mimicking schwannoma Same, HE,  IH - EMA, S-100
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20/2/16
New Cases of Neuroimaging & Neuropathology: 
M. 32 yr.   Neurotuberculosis in rare presentation with symmetrical necrotizing vasculitis of midline cerebral cortex and corpus callosum Same, HE, epithelioid and giant cell granuloma Same, HE, acute necrotizing vasculitis with fibrin deposits and hemorrhagic infarction of cerebral cortex Same,  Masson's trichrome and Ziehl-Neelsen stain showing acid-fast bacilli in necrotic brain tissue 
M. 63 yr.   Fronto-temporal gliosarcoma  Same, specimen. Area of glioblastoma : HE, Masson's trichrome, Gomori's silver for reticulin fibers Same, glioblastoma, immunohistochemistry for GFAP, neuronal antigens Same, glioblastoma, IH for CD34, 1A4, Ki67, p53
Same, gliosarcoma, HE, Masson's trichrome, Gomori's silver for reticulin  Same, gliossarcoma, IH for GFAP, S-100, VIM Same, gliossarcoma, IH for CD34, 1A4, Ki67, p53
M. 51 yr. Pilocytic astrocytoma of cerebellum with unusually luxuriant capillary proliferation (prompting differential diagnosis with hemangioblastoma)  Same,  HE, GFAP. Pictured : astrocytoma islets amid proliferated capillaries Same, CD34, Ki67, and differential diagnosis with hemangioblastoma : inhibin, NSE, S100
F. 67 yr.  Pilocytic astrocytoma of retina Same,  HE, GFAP, VIM, S100, Ki67, text M. 64 yr. Pseudotumoral paracoccidioidomycosis  of cerebellum Same, HE, Grocott, PAS
F. 21 yr.  Fibrous dysplasia of skull Same, specimen, HE, text Same, Masson's trichrome
...
27/12/15
New Cases of Neuroimaging & Neuropathology: 
F. 62 yr.   Cerebral bacterial abscess. 3 MRIs showing lesion regression with treatment Same, massive subarachnoid hemorrhage one week after 3rd MRI  At autopsy - systemic aspergillosis. Gross appearance of brain Same, aspergillosis of brain (pictured - Aspergillus phlebitis amid subarachnoid hemorrhage)
Same, residual abscess cavity in white matter of superior temporal gyrus Same, pulmonary aspergillosis. HE, Grocott  Same, Aspergillus abscesses in left ventricle HE, Grocott. Hepatitis C liver cirrhosis
F. 67 yr.  Rhino-orbital aspergillosis Same, Aspergillus in necrotic tissue of maxillary sinus and orbit.  - HE, PAS, Grocott. Text F. 31 yr.  Cysticercosis cellulosae of brain hemispheres and IV ventricle Same, IV ventricle cysticercus. Stereomicroscopic images, histology with degenerative changes
M. 8 mth. Congenital cerebral teratoma. 6 month follow up with CT, MRI Same, 2nd. biopsy at 8 mth including nervous tissue and teeth. HE  Text Same, 1st. biopsy at 2 mth showing only malformed brain tissue. Immunohistochemistry
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4/11/15
New Cases of Neuroimaging & Neuropathology: 
F. 32 yr.   Dysplastic gangliocytoma of  cerebellum  (Lhermitte-Duclos disease). MRI Same, full blown changes, specimen, HE Same,  LFB-Nissl  Same,  immunohistochemistry for MAP2, NeuN, synaptophysin
Lhermitte-Duclos: image bank, text
Same, IH for NF, chromogranin Same, IH for GFAP, S100 Same,  IH for CD34, CD68, Ki67 Same, partial changes, specimen, HE
Same, LFB-Nissl Same, IH for MAP2, NeuN Same, IH for GFAP, CD34, CD68, Ki67
M. 22 yr.   Dysplastic gangliocytoma of  cerebellum  (Lhermitte-Duclos disease). MRI Same, HE, LFB-Nissl Same, IH for MAP2, NeuN, synaptophysin Same, IH for NF, chromogranin
Same, IH for GFAP, CD34, Ki67 M. 22 yr.  Same patient, normal cerebellar cortex. HE, LFB-Nissl Same, IH for MAP2, NeuN, NF, synaptophysin Same, IH for GFAP, S100, CD34
F. 45 yr.   Dysplastic gangliocytoma of  cerebellum  (Lhermitte-Duclos disease). MRI - two distinct lesions in right cerebellar hemisphere Same, HE, LFB-Nissl, lesions at different phases
M. 32 yr.   Cerebral  granulomatous cryptococcosis: 
circumscribed meningeal, cerebral lesions 
Same, HE, Masson's trichrome, Grocott, mucicarmine, PAS Cerebral  cryptococcosis: non specific and granulomatous inflammation in meninges and parenchyma. HE, PAS
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5/10/15
New Cases of Neuroimaging & Neuropathology: 
F. 6 yr 7 m.   Angiocentric glioma  in left superior frontal gyrus Same, specimen, HE, text Same, special stains Same, IH for glial antigens
Same, IH for neuronal antigens Same, IH for EMA, CD34, Ki67, p53 F. 57 yr.   Primary cerebral vasculitis Same, HE
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9/8/15
General Pathology - new pages for undergraduates: 
Mallory's hyaline change in hepatocarcinoma cells Hyaline nodules in glomeruli in diabetes mellitus (intercapillary  glomerulosclerosis of Kimmelstiel-Wilson) Acute tubular necrosis of kidney in shock  Diffuse amyloidosis of lymph node (pictured - Congo red stained section under polarized light)
Squamous metaplasia of trachea in prolonged intubation Bone metaplasia of tracheal cartilage Mammary fibroadenoma Mammary adenocarcinoma
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10/7/15
Atlas of the normal human hippocampus 
  HE LFB-Nissl MAP2
Index page
Neurofilament Synaptophysin Chromogranin GFAP
Vimentin CD34 CD68 HAM56
Texts (in Portuguese): 

Structure of the  hippocampus, dentate gyrus, subiculum.

Hippocampal connections and diagram.

...
18/5/15
New Cases of Neuroimaging & Neuropathology: 
F. 37 yr.   Pituitary carcinoma  with pulmonary metastases. 6-year follow up.  CT, MRI, highlights Same, exams in full. Text Same, first biopsy of pituitary tumor, 2009. HE, IH  Same, second biopsy of pituitary tumor, 2015. HE, IH 
Same, lung biopsy, 2014.  HE, IH  F. 70 yr. Rathke's cleft cyst.  MRI Same, HE
F. 62 yr. Thoracic epidural meningeal cyst. MRI Same, HE M. 11 yr. 6 m. Intradural cervical and lumbar lipomas. MRI Same, specimen, HE, Masson's trichrome, IH. Text
M. 36 yr.   Fronto-parietal mesial pleomorphic xanthoastrocytoma  Same, HE Same, IH -  GFAP, VIM, S100, NF Same, IH - CD34, CD99, 1A4, Ki67, p53
M. 11 yr. Frontal pleomorphic xanthoastrocytoma Same, HE Same, IH - GFAP, VIM Same, IH - S100, NF, chromogranin, 1A4
Same, IH - CD34, CD99, Ki67, p53 M. 12 yr. Plexiform neurofibroma  of tongue. HE, Masson's trichrome Same, IH - NF, CD57, S100, EMA
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20/2/15
New Cases of Neuroimaging & Neuropathology:
F. 20 yr.    Anaplastic and clear cell  meningioma of posterior fossa with supratentorial extension. CT, MRI Same, specimen, HE, anaplastic part Same, HE, clear cell part Same, Masson's trichrome
Same, reticulin, PAS in clear cell part, before and after amylase digestion Same, immunohistochemistry for EMA, VIM Same, IH, S-100, CD57, 1A4, HHF35. Pictured - axons in cranial nerve root infiltrated by tumor Same, IH, CD34, Ki-67, p53
F. 26 days.  Congenital anaplastic astrocytoma of temporal lobe. CT Same, specimen, HE Same, IH
F. 67 yr.   Invasive pituitary adenoma with extensive skull base infiltration. CT, MRI Same, HE, smear, paraffin sections Same, IH. Pictured - invasive adenoma adjacent to respiratory epithelium
F. 22 yr.  Cerebral metastases of choriocarcinoma 6 years after molar pregnancy. CT, MRI  Same, specimen, HE Same, IH
..
Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
...
General and Special Pathology Neuropathology and Neuroimaging Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histopathological  staining  methods
.....