Pathology  -  Neuropathology   -   Neuroimaging
New  additions  (2019 to present)
..
Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016 2017, 2018 2019, 2020
...
Updated 6/6/2020
General and Special Pathology 
e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese New additions Histopathological  staining  methods
.......
6/6/2020
New Cases of Neuroimaging & Neuropathology:
M. 2 yr 10 m. Pilomyxoid astrocytoma  Same, 1st sample, 2018.  HE, Masson's trichrome Same, IH - GFAP, vimentin, CD34, Ki67.  Text Same, 2nd sample, 2020.  HE, Masson's trichrome
Same, IH - GFAP, vimentin, CD34, Ki67 M. 1 yr 6 m. Pilomyxoid astrocytoma  Same, HE, Masson's trichrome, IH - GFAP, vimentin, CD34, Ki67.  Velpeau's law
M. 2 yr 5 m. Right frontal dysembryoplastic neuroepithelial tumor (DNET)  Same, macro, HE  Same, IH - GFAP, vimentin Same, IH - synaptophysin, MAP2, neurofilament 
Same, IH - SMI-32, NeuN, Ki67 F. 12 yr 4 m. Anaplastic astrocytoma  of lumbar spinal cord and cauda equina  progressing to extensive ischemic necrosis Same, HE Same,  IH - GFAP, synaptophysin, neurofilament, CD68, CD34, Ki67
F. 2 yr 10 m.  Cerebral metastasis  of hepatoblastoma Same,  macro Same,  HE, texts hepatoblastoma Same,  Masson's trichrome, IH - a-FP, AE1AE3
Same,  IH - b-catenin, Ki67.  Texts a-FP, b-catenin M. 16 yr 2 m.  Malignant peripheral nerve sheath tumor (MPNST) in left L4 spinal root. Pictured  -  intra and extraforaminal components Same,  HE,  Masson's trichrome,  reticulin. 
Text - MPNST
Same, IH -  neurofilament, S-100
Same, IH -  Vimentin, CD56, CD57, CD34,  Ki67 Same, normal posterior root ganglion of same case.  HE, Masson's trichrome,  reticulin Same, IH -  neurofilament, S-100, Vimentin, CD56, CD57, CD34
Note.  Pictures of normal posterior root ganglion also added to Neuro image bank.  Click for  HE, special stains and  immunohistochemistry
.......
22/2/2020
New Cases of Neuroimaging & Neuropathology:
F. 5 yr 7 m.  Inflammatory myofibroblastic tumor at skull base (jugular foramen).  5-year MRI follow-up.  Same, HE Same, Masson's and Goldner's trichromes.   Text : Inflammatory myofibroblastic tumor Same, IH for vimentin 
Same, HHF-35, 1A4, calponin. Text : calponin, caldesmon Same, CD3, CD20, CD68, CD138 Same, S100, IgG, IgG4,  CD99, CD34,  Ki67. 
Text : IgG4 disease
F. 18 yr 6 m. 
Lipidized anaplastic ependymoma ectopic at parietal cerebral cortex.  Original tumor in 2015. Recurrence in 2019. 4-year MRI follow-up. 
Same,  original tumor, HE.  Texts : ectopic ependymoma 
lipidized 
ependymomas 
Same, EMA, AE1AE3, GFAP, vimentin, 1A4, NF, SNF, Ki67, p53 Same, recurrence. HE, Masson's trichrome. Picture - lipidized tumor cells
Same, recurrence.  EMA, AE1AE3, GFAP, vimentin, Ki67
M. 10 yr 5 m.  Ganglioglioma  of lumbar spinal cord. 7-year MRI follow-up,   5 exams Same, 1st. sample 2012.  HE, IH - GFAP, vimentin, 
synaptophysin, MAP2, NeuN, NF, CD56, CD34, Ki67
Same, 2nd. sample 2019.  HE, IH - GFAP, vimentin, 
synaptophysin, MAP2, NeuN, NF, CD56, CD34, Ki67
Same, comparison of  2 samples. 
Table - CD34 in 32 gangliogliomas posted on this website 
M. 10 m. Congenital sacral chordoma associated with tuberous sclerosis complex Subependymal nodules, some calcified Same, HE.  Text : chordomas in the pediatric population Same, IH - AE1AE3, EMA, vimentin, S-100,  Ki67.
M. 5 yr 3 m.  Diffuse midline glioma Same, HE Same, IH - GFAP, NF,  CD34,  Ki67
M. 15 yr 6 m.  Langerhans cell histiocytosis in sphenoidal sinus.  Same, HE Same, IH - CD1A, CD68, S-100
........
31/12/2019
New Cases of Neuroimaging & Neuropathology: 
F. 17 yr 6 m.  Composite ganglioglioma  + pleomorphic   xanthoastrocytoma-   MRI Same,  Case summary.  Text. Same,  ganglioglioma  component - HE, Masson's trichrome, reticulin Same,   ganglioglioma - IH for glial antigens  - GFAP, vimentin
Same, ganglioglioma - 
IH for neuronal antigens - chromogranin, MAP2, NeuN, SMI-32, synaptophysin
Same, ganglioglioma - IH for CD34,  Ki67 Same,  xanthoastrocytoma  component - HE, Masson's trichrome, reticulin Same, xanthoastrocytoma  -  IH for GFAP, vimentin, chromogranin, CD34, Ki67
M. 46 yr. 
Diffuse brainstem glioma infiltrating cerebellum and producing secondary structures of Scherer in the molecular layer. 
Same,  HE  (pictured - 
subpial accumulation of gliomatous cells (secondary structures of Scherer). 
Same, synaptophysin Same, Ki67, p53
F. 8 yr 7 m.  Pilocytic astrocytoma of medulla in NF1 Same,  HE, IH  for NF.  (pictured -  Rosenthal fibers)
M. 5 yr 4 m. Plexiform neurofibroma circling the  cervical spine in NF1 Same, HE, Masson Same, IH -  S-100,  NF,  vimentin, EMA, CD56,  CD57
....
30/9/2019
New Cases of Neuroimaging & Neuropathology: 
F. 2 yr. 10 m.  Embryonal tumor with multilayered rosettes, medulloepithelioma and ependymoblastoma morphology. CT, MRI  Same,  HE Same,   Masson Same, IH -  GFAP 
Same, IH -  synaptophysin, MAP2 Same, IH -  vimentin, nestin (text), AE1AE3, 1A4 Same, IH -  CD56, CD99, S100, HMB45, INI1 Same, IH -  CD34,  Ki67, p53.  Text
M. 2 yr. 1 m. Undifferentiated sarcoma of skull base. CT, MRI Same, HE  - Masson and  Goldner trichrome stains Same, IH - vimentin, 1A4, CD68, Ki67 
F.  6 m.  Diffuse symmetrical hyperplasia of choroid plexus of lateral ventricles. CT Same,  macro, HE, Masson, reticulin Same,  IH - GFAP, vimentin,  S-100, EMA, CD34, Ki67
M. 1 yr. 2 m.  Choroid plexus papilloma of right lateral ventricle. CT, MRI Same,  macro, HE, Masson Same,  IH - AE1AE3, EMA, GFAP, vimentin Same,  IH - S100, CD34, Ki67, INI1
M. 10 m 17 d.  Choroid plexus papilloma of  IV ventricle.  CT, MRI Same, macro, HE, Masson Same,  IH - AE1AE3, EMA, GFAP
Same, IH - vimentin, S100, CD34, Ki67, p53 M. 7 m 11 d. Choroid plexus carcinoma of left lateral ventricle. CT, MRI Same,  HE Same,  IH - vimentina, AE1AE3, S100, CD34, Ki67, p53
Same case, normal choroid plexus. HE.  Same, IH - vimentin, AE1AE3, GFAP, S-100, EMA, CD56, CD34
.....
6/6/2019
New Cases of Neuroimaging & Neuropathology:
F. 8 yr 4 m.  Embryonal tumor of the CNS with abundant neuropil and multilayered rosettes. MRI Same,  Macro.  Same,   HE Same,   HE
Same, IH -  GFAP, vimentin Same, IH -  synaptophysin, NF Same, IH -  NeuN, MAP2, SMI32, chromogranin Same, IH -  CD34,  Ki67
M. 12 yr 7 m.  Clear cell ependymoma, RELA fusion positive.  CT Same,  HE  Same, IH - EMA, GFAP, L1CAM, Ki67.  Texts :  RELA fusion ependymomas, C11orf95, RELA, L1CAM 
M. 8 yr 1 m.   Primary intracerebral sarcoma.  MRI Same,  HE, Masson Same,  IH - GFAP, S-100, vimentin, desmin, HHF-35, 1A4, CD34, Ki67 
M. 12 yr 6 m. Temporal ganglioglioma.  MRI Same, HE Same, IH - GFAP, MAP2, SMI32, chromogranin, NeuN, CD34, Ki67
........
24/4/2019
New Cases of Neuroimaging & Neuropathology:
M. 4 yr 7 m.  Fibrous dysplasia of skull base.  CT, MRI Same.  Preliminary transnasal biopsies.  HE.  Same.  Surgical specimen.  HE Same, IH -  Vimentin, CD68, HAM56
Same, IH -  1A4, HHF-35,  CD34,  Ki67 F. 3 yr 3 m. Diffuse midline glioma Same, HE,  IH - GFAP,  vimentin, NF, CD34,  Ki67
M. 10 yr. Epithelioid glioblastoma of left temporal lobe Same,  HE.  Same, IH - GFAP, vimentin, S-100,  EMA Same, IH - SNF,  NF,  CD34,  Ki67.  Text
M. 5 yr. Multifocal cerebral aspergillosis. TC. MRI Same, HE Same, Grocott
.....
2/2/2019
New Cases of Neuroimaging & Neuropathology:
F. 1 yr.   Atypical teratoid/rhabdoid tumor (ATRT) in anterior surface of brain stem. CT, MRI Same,  HE, Masson Same,  IH - vimentin, 1A4, AE1AE3, EMA Same,  IH - CD34, INI-1, Ki67. 
F. 3 yr 5 m. Choroid plexus carcinoma of right lateral ventricle after two cycles of chemotherapy. MRI Same, HE Same,  IH  - vimentin,  GFAP, AE1AE3, EMA, synaptophysin,  neurofilament, CD34, Ki67, p53
F. 4 m. Choroid plexus carcinoma of left lateral ventricle, presumably congenital. MRI Same,  HE Same,  IH  - AE1AE3, vimentin,   synaptophysin,  neurofilament, CD34, Ki67, p53 
M. 36 yr. Brown tumor of hyperparathyroidism in L5 vertebra.  CT Same, HE, Masson.  Texts:  hyperparathyroidism, brown tumor. Same, IH - CD68, HAM5.6, 1A4, vimentin, CD34, Ki67. 
F. 63 yr.  Presacral myelolipoma. MRI Same, HE Same, IH - HB, MPX, CD61.   Text
F. 31 yr.   Fibrous dysplasia of skull. CT. Same,  specimen Same, HE
.
Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016 2017, 2018 2019, 2020
...
Updated 22/2/2020
General and Special Pathology 
e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese New additions Histopathological  staining  methods
......