Pathology  -  Neuropathology   -   Neuroimaging
Additions  posted  2009 - 2010
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
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Updated 27/12/15
General and Special Pathology 
e-mails : gradanat@fcm.unicamp.br____gradanat@unicamp.br
Neuropathology and Neuroimaging Cases correlating Neuroimaging + Neuropathology Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histopathological  staining  methods
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28/12/10
New Cases of Neuroimaging & Neuropathology:
M. 29 yr.  Germinoma of pineal Same, specimen, HE Same, immunohistochemistry for PLAP, c-kit, b-HCG, AE1AE3.  Same, IH - CD20, CD3, vimentin, Ki-67.
Text : germinal tumors Text : tumors of pineal parenchyma Texts: PLAP, c-kit
M. 21 yr.  Germinoma of pineal M. 19 yr.  Germinoma of pineal M. 9 yr.  Germinoma of pineal M. 28 yr. Germinoma of pineal
F. 12 yr.  Germinoma of  hypothalamic region M. 21 yr. Germinoma of  hypothalamic region infiltrating dorsum sellae, cavernous sinuses and compressing optic chiasm  Same, HE, special stains, IH - c-kit, Ki-67 M. 9 yr. Germinoma of pineal. Seeding of cranial subarachnoid space and lumbar nerve roots. Two-year follow-up. 
F. 16 yr. Germinoma of  hypothalamic region disseminating to IV ventricle Same, HE M. 17 yr. Germinoma of pineal with non caseating, epithelioid cell granulomas. HE Same, IH -  PLAP, c-kit, CD3, CD20, CD68
Same, IH - VIM, AE1AE3, GFAP, NF, Ki-67, p53 F. 24 yr. Pineocytoma.  Histology for this case already available  F. 20 yr. Pineoblastoma. Histology for this case already available  M. 15 yr. Pineoblastoma
F. 14 yr. Pineoblastoma Same, HE, special stains Same, IH
F. 58 yr. Three-lobed cyst of pineal Same, HE, IH M. 13 yr. Teratoma of pineal. Free lipid droplets in lateral ventricles
M. 1 yr.  Desmoplastic infantile astrocytoma Same, HE, text Same, special stains Same, IH - GFAP, VIM, synaptophysin
Neuro  Image  Bank
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Same, IH - CD34, 1A4, Ki-67, p53 Pineal tumors  Brain stem gliomas
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15/11/10
Neuro  Image  Bank  :
Anatomy of the Skull and Brain in Coronal Sections.  Correlation between anatomical specimens, histology, computerized tomography (CT) and magnetic resonance imaging (MRI). 
Atlas of the human brain in coronal sections

Collaboration 

Dept of Pathology
FCM - UNICAMP

Dept of Anatomy, Cell Biology,  Physiology and  Biophysics,  IB - UNICAMP

Normal skull in coronal CT, soft tissue settings Normal skull in coronal CT, bone settings Normal skull in coronal MRI, T1-SE (spin echo) Normal skull in coronal MRI, T1-IR (inversion recovery) and T2 (comparative series)
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7/11/10
New Cases of Neuroimaging & Neuropathology:
M. 49 yr.  Gliosarcoma of left frontal lobe Same, specimen, HE  Same, special stains Same, immunohistochemistry : GFAP, VIM, 1A4, desmin
Same, IH :  CD34, Ki67, p53 F. 5 months. Glioblastoma multiforme of left cerebral hemisphere (presumably congenital) Same, HE
M. 29 yr. Left parietal primitive neuroectodermal tumor (PNET)  Same, HE, reticulin  Same, IH : GFAP, VIM, S-100, NF, synaptophysin, NSE, chromogranin Same, IH : CD56, CD99, EMA, CD34, Ki67, p53
F. 49 yr. Pseudotumoral demyelinating lesions in right cerebral hemisphere Same, HE Same, IH
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6/9/10
New Cases of Neuroimaging & Neuropathology:
M. 15 yr.  Occipital paraventricular pleomorphic xanthoastrocytoma  Same, HE  Same, special stains Same, immunohistochemistry : GFAP, VIM, NSE, NF
Case summary.  Text : Pleomorphic xanthoastrocytoma
Same, IH :  CD34, Ki67, p53 Same, recurrence after  five years Same, specimen, HE, special stains. Text: connective tissue fibers Same, IH
F. 27 yr. Giant cell glioblastoma Same, smear, frozen sections Same, paraffin, HE Same, IH : GFAP, VIM, S-100, NF
Case summary.  Text : Giant cell glioblastoma
Same, IH : CD34, Ki67, p53 Same, Araldite embedded, toluidin blue stained 1 mm sections Same, electron microscopy
M. 3 months. Choroid plexus carcinoma Same, HE Same, IH
M. 45 yr. Cervical epidural meningeal cyst Same, specimen, HE, text F. 15 yr. Multiple epidural meningeal cysts Same, specimen, HE
Text : epidural meningeal cyst  or spinal extradural arachnoid cyst
F. 27 yr. Intradiploic arachnoid cyst Same, HE, text
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7/7/10
New Cases of Neuroimaging & Neuropathology:
M. 22 yr.  Ganglioglioma of cerebellum Same, specimen, HE, special stains Same, immunohistochemistry Same, electron microscopy (pictured - astrocytic processes rich in intermediate filaments). Text:  endothelial cells
F. 13 yr.  Severe multiple sclerosis in early adolescence.  Two-year follow up Same, HE Same, IH
M. 25 yr.  Hypothalamic hamartoma  Same, specimen, HE Same, IH F. 3 yr. Hypothalamic hamartoma 
F. 3 yr. Hypothalamic hamartoma  Same, HE F. 1 yr. 7 m. Cystic hypothalamic hamartoma 
M. 49 yr. Giant invasive pituitary adenoma infiltrating skull base and nasopharynx  Same, HE Same, IH
F. 37 yr. Anaplastic primitive neuroectodermal tumor  (PNET) of left frontal lobe.  Same, specimen, smear, frozen sections Same, paraffin sections, HE Same, IH (GFAP)
Neuro Image Bank 
Same, IH, other markers (pictured - positivity for chromogranin) Same, EM (pictured -  neuropil of fine tumor cell processes) Polymicrogyria Chordoma
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23/5/10
New Cases of Neuroimaging & Neuropathology:
M. 17 yr. Primary myxoid sarcoma of brain. Early lesion in left parietal lobe Same, HE, IH  Same, first recurrence at left temporal lobe after 6 months  Same, second recurrence after 3 years, elsewhere in left parietal lobe
Case  summary
Same, HE, IH (high grade undifferentiated sarcoma) Same, third recurrence after 4 years at left frontal lobe Same, specimen, HE Same, Masson's trichrome
Same, IH Same, electron microscopy F. 26 yr. Myxopapillary ependymoma  Same, HE
M. 4 d.  Congenital PNET (primitive neuroectodermal tumor) of cerebral hemisphere with ependymal and neuroblastic differentiation.  Same, HE Same, IH Spinal ependymoma featuring numerous ependymal canals and rosettes.  HE
F. 15 yr. pPNET (peripheral primitive neuroectodermal tumor) / Ewing's sarcoma of spinal epidural space (T11-T12) compressing cord and nerve root .  Same, HE Same, IH M. 17 yr. Subependymal giant cell astrocytoma. HE, IH
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9/4/10
New Cases of Neuroimaging & Neuropathology:
F. 75 yr. Metastatic adenocarcinoma in sphenoid wing mimicking meningioma on MRI Same,  HE (Pictured : neoplastic cells in Haversian canal and new bone deposition) Same, immunohistochemistry
M. 59 yr. Metastatic neuroendocrine carcinoma in cerebral hemisphere Same, HE, special stains Same, IH
F. 25 yr. Extradural capillary hemangioma of ligamentum flavum compressing thoracic spinal cord Same, macro specimen, HE Same, Masson's trichrome Same, IH
F. 37 yr.  Rathke's cleft cyst. CT, MRI Same, HE, special stains F. 46 yr. Rathke's cleft cyst. MRI F. 42 yr. Rathke's cleft cyst. MRI
M. 43 yr. Colloid cyst of third ventricle. CT F. 62 yr. Colloid cyst of third ventricle. CT M. 14 yr. Colloid cyst of third ventricle. CT, MRI M. 36 yr. Colloid cyst of third ventricle causing  unilateral hydrocephalus. CT, MRI
Neuro Image Bank 
M. 40 yr. Colloid cyst of third ventricle. CT, MRI M. 61 yr. Colloid cyst of third ventricle causing  bilateral hydrocephalus. CT, MRI Colloid cyst of third ventricle. Text Rathke's cleft cyst. Text. Hyperprolactinemia Text.
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18/2/10
New Cases of Neuroimaging & Neuropathology:
M. 33 yr. Hemangiopericytoma with falx attachment Same, specimen, HE, special stains Same, immunohistochemistry. Text: Hemangiopericytomas Same, electron microscopy
M. 4 d. Congenital gliosarcoma at foramen of Monro, hydrocephalus, spontaneous ventricular bleeding Same, smear, frozen sections, HE, special stains Same, IH Same, EM
F. 28 yr.  Neuroblastoma of olfactory nerve (esthesioneuroblastoma) M. 36 yr.  Esthesioneuroblastoma with frontal lobe extension M. 46 yr. Esthesioneuroblastoma causing frontal lobe hemorrhage Same, HE, IH. 
Pictured: Homer Wright rosette
F. 57 yr. Capillary telangiectases  associated with cortical dysplasia  Same, specimen, HE Same, special stains Same, IH - CD34, GFAP, Ki67
Neuro image bank
»»»
Same, IH - neuronal antigens. Pictured: dysplastic neurons with synaptic boutons. Comment Comparison of anatomical specimens, CT and MRI of nasal cavity and frontal region (to illustrate cases of esthesioneuroblastoma)
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30/12/09
New Cases of Neuroimaging & Neuropathology:
F. 68 yr. Skull metastasis of follicular adenocarcinoma of thyroid Same, macro, HE Same, immunohistochemistry Same, electron microscopy.  Text : thyroid histophysiology
F. 49 yr. Subependymoma of lateral ventricle Same, macro, HE Same, IH Same, EM
F. 54 yr. Paraganglioma of cauda equina Same, macro, HE, special stains Same, IH. Text : spinal paragangliomas 
M. 47 yr. Frontal arteriovenous malformation (AVM) Same, macro, HE Same, special stains
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9/12/09
New Cases of Neuroimaging & Neuropathology:
F. 36 yr. Choroid plexus papilloma of fourth ventricle Same, macro, HE, special stains Same, IH Comparison between papilloma and carcinoma of choroid plexus. Text on choroid plexus tumors
F. 32 yr. Choroid plexus papilloma of third ventricle F. 9 m. Choroid plexus papilloma of lateral ventricle. Twelve year follow up M. 30 d. Congenital choroid plexus papilloma of lateral ventricle M. 26 yr. Calcified choroid plexus papilloma of fourth ventricle
M. 52 yr. Choroid plexus papilloma of the lateral recess of the fourth ventricle  (at foramen of Luschka) Related anatomical preparations (arrow, choroid plexus at lateral recess of fourth ventricle) F. 1 yr 7 m. Choroid plexus carcinoma of lateral ventricle with  seeding through CSF pathways Same, macro, HE
Same, IH Same, EM Same case, area of normal choroid plexus.  HE, special stains, IH
M. 28 yr. Multiple schwannomas of cauda equina Same, macro, HE, special stains Same, IH (picture, Antoni B pattern) Same, EM  (arrows, basal lamina enveloping Schwann cell)
M. 26 yr. Peripheral primitive neuroectodermal tumor (pPNET) of cauda equina Same, macro, HE, special stains Same, IH (picture, infiltrated nerve root)
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3/11/09
New Cases of Neuroimaging & Neuropathology: 
M. 24 yr. Occipital pilocytic astrocytoma featuring grossly abnormal vessels, leptomeningeal and parenchymal infiltration and ventricular seeding. CT Same, MRI Same, first specimen,
macro, HE
Same, special stains
Case summary

Text:  pilocytic astrocytomas

Same, immunohistochemistry. Pictured: Rosenthal fibers Same, second specimen, HE. Pictured: leptomeningeal infiltration Same, Masson's trichrome Same, IH. Pictured: leptomeningeal infiltration
M. 63 yr. Cerebellar pilocytic astrocytoma with atypia and high Ki-67 index. MRI Same, HE. Pictured: oligodendroglioma-like tissue Same, IH. Pictured: high Ki-67 index in atypical area 
F. 75 yr. Fibroblastic
meningioma of left lateral ventricle. CT, MRI
Same, macro, HE M. 25 yr. 
Dermoid cyst (mature cystic teratoma) of sellar region. Spread of lipid droplets through the subarachnoid space and lateral ventricle. MRI
Same, macro, HE, Text
M. 38 yr. Left parietal cavernoma (cavernous hemangioma) extending from ventricle to hemispheric surface. MRI, digital angiography (normal) Same, macro, HE Same, special stains.  Pictured: organized thrombus Same, IH. Pictured: gliotic nervous tissue among dilated vessels
M. 33 yr.  Epidermoid cyst of right choroid fissure and arachnoid cyst of posterior fossa. CT, MRI Same, macro, HE of epidermoid cyst. Text
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27/7/09
New Cases of Neuroimaging & Neuropathology: 
M. 4 yr.  Tanycytic ependymoma of third ventricle and foramina of Monro Same, HE. Text Same, IH
M. 6 yr. Right sided parieto-occipital tanycytic ependymoma Same,  macro specimen, HE, special stains Same, IH
M. 24 yr. Spinal enterogenous cyst  Same, HE, special stains Same, IH Same,  electron microscopy
F. 59 yr.  Left sided temporal glioblastoma multiforme  Same, HE Same case 9 months after surgery and radiotherapy - pseudotumoral radiation necrosis  Same, HE, Masson's trichrome
Same, IH F. 28 yr.  Large occipital cavernoma (cavernous hemangioma) Same, macro specimen, HE Same, Masson's trichrome, immunohistochemistry for CD34
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16/6/09
New Cases of Neuroimaging & Neuropathology: 
F. 32 yr. Solid-cystic ganglioglioma
with pilocytic glial component in cerebellum
Same, macro specimen Same, HE Same, special stains
Same, immunohistochemistry Same,  electron microscopy. Picture: hyaline granular body F. 56 yr. Marginal zone non Hodgkin B cell lymphoma of skull base at left cavernous sinus Same, HE, IH  Texts.
F. 45 yr.  Plasmacytoma of skull base Same, HE - smear, frozen and paraffin sections. Text Same, IH Same, EM
M. 62 yr. Anaplastic pilocytic astrocytoma of right frontal lobe Same, HE Same, IH
Neuro Image Bank

Atlas of middle and inner ear 
»»»

Collaboration of

Dept of Anatomy 
IB - UNICAMP 

Dept of Pathology
FCM - UNICAMP

...
19/5/09
New Cases of Neuroimaging & Neuropathology: 
M. 44 yr. Adamantinomatous craniopharyngioma  extending into third ventricle Same,  macro specimen under stereomicroscope Same, HE, tumor epithelium Same, HE, bone metaplasia, pilocytic gliosis. Text:  craniopharyngiomas
Same, ghost cells and bone in polarized light Same, special stains (Masson's trichrome, von Kossa for calcium) Same, electron microscopy F. 31 yr. Adamantinomatous craniopharyngioma. Cholesterol crystals in polarized light
M. 54 yr.   Adamantinomatous craniopharyngioma.  Large cyst filling prepontine cistern and  third ventricle Same, macro specimens, HE Same, special stains (Masson's trichrome, Gomori's silver for reticulin) Same, immunohistochemistry 
Same,  electron microscopy M. 44 yr. Adamantinomatous craniopharyngioma extending into frontal lobes  Same, macro specimen, HE (picture, cyst wall)
M. 31 yr.  Neuroimaging appearance suggestive of craniopharyngioma. 
Large third ventricle cyst with fluid level
Same, HE:  Pilocytic gliosis and cholesterol granulomas, but no craniopharyngioma tissue found.  Text: alpha B-crystallin Same, IH: Pilocytic gliosis - GFAP, HAM-56, CD68 Same, IH: Pilocytic gliosis -  CD34, AE1AE3, EMA, Ki-67
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28/2/09
New Cases of Neuroimaging & Neuropathology: 
F. 29 yr.  Complex meningioma combining rhabdoid, papillary  and clear cell patterns. CT, MRI Gross specimen, smear, frozen sections  Rhabdoid areas, 
HE, special stains
Rhabdoid areas, IH
Case summary
Rhabdoid areas, EM Papillary areas, 
HE, special stains
Papillary areas, IH Clear cell areas, 
HE, special stains
Texts (in Portuguese):

rhabdoid
meningioma

papillary
meningioma 

clear cell meningioma

 

Clear cell areas, IH Clear cell areas, EM
M. 49 yr.  Xanthomatous and angiomatous meningioma of left parietal convexity, CT, MRI Gross specimen, HE Special stains IH
 EM F. 66 yr. Parafalcine meningioma with microcystic, xanthomatous, angiomatous and meningothelial  components. CT, MRI Gross specimen, HE
Special stains IH EM 
M. 56 yr. Left temporal gliosarcoma, MRI HE Special stains IH, text
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7/1/09
New Cases of Neuroimaging & Neuropathology: 
F. 40 yr. Frontoethmoidal (frontonasal) cephalocele Same, HE, Masson's trichrome Same, IH F. 5 yr. 
Frontoethmoidal (fronto-orbital) cephalocele
Same, HE, Masson's trichrome F.  52 yr. Lipidized meningioma  (with adipose tissue metaplasia) of petrous apex F.  57 yr. Temporal lipidized meningioma  M.  51 yr. Lipidized meningioma of sphenoid wing 
Same, HE Same, special stains Same, IH Same, electron microscopy
F. 42 yr. Recurrent chordoid meningioma invading frontal sinus Same, HE, IH F. 37 yr. Ewing's sarcoma / primitive neuroectodermal tumor (PNET) of lumbar nerve roots invading vertebrae Same, HE, special stains, IH
M. 21 yr. Primitive neuroectodermal tumor (PNET) of lumbar nerve roots with paravertebral soft tissue extension Same, HE, special stains Same, IH M. 56 yr. Subependymoma of lateral ventricle. EM  (completes case)
Neuro Image Bank 
»»»
F.  2 yr 5 m.  Ependymoblastoma of cerebral hemisphere. EM (completes case) »  Completion of existing page Anatomy of skull. Coronal sections of intact head, brain in situ.  - complete 12 double-faced slice series 
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Additions of  2004  to  2006
2007,  2008
2009,  2010 2011,  2012 2013, 2014 2015, 2016
...
General and Special Pathology Neuropathology and Neuroimaging Neuroimaging Basics Neuroimaging - Cases
Alphabetical index (Pathology) Alphabetical index (Neuro) Neuro Image Bank Neuropathology - Cases
English Homepage This page in Portuguese Site in Portuguese Histological methods
.....