Neupatimagem UNICAMP

Pathology - Neuropathology - Neuroimaging
Additions posted 2007 - 2008 ...

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Updated 5/1/2020	General and Special Pathology	e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

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30/11/08
New Cases of Neuroimaging & Neuropathology:

M. 43 yr. Right parietal astroblastoma	Same, HE	Same, IH	Same, IH, text


F. 48 yr. Pseudotumoral demyelinating lesion of cerebral hemispheric white matter	Same, HE	Same, IH	Same, IH


M. 42 yr. Chondroma of skull base at petrous apex / cavernous sinus	Same, HE, IH, text	F. 67 yr. Necrotic cysticercus cellulosae of cerebral hemisphere - reactional changes in brain tissue	Same, specimen, HE.


F. 60 yr. Primary dural lymphoma with extracranial extension. 12-year follow-up	Same, HE. Picture: lymphomatous infiltration of temporal muscle	Same, IH, text : inflammatory pseudotumor


F. 43 yr. Chordoid glioma of third ventricle	Same, HE	Same, IH, text

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2/10/08
New Cases of Neuroimaging & Neuropathology:

F. 15 yr. Bilobed, solid and cystic pilocytic astrocytoma of cerebellum with abundant vascular proliferation	Same, surgical specimen, HE	Same, special stains	Same, IH


F. 29 yr. Solid-cystic right parietal ganglioglioma with features of xanthoastrocytoma	Same, surgical specimen, smears, scanned histological slides	Same, HE	Same, special stains


Same, IH - GFAP	Same, IH - neuronal markers	Same, IH - CD34, Ki-67


M. 27 yr. Schwannoma of trigeminal nerve root or of Gasserian ganglion	Same, surgical specimen, HE	Same, special stains	Same, IH


M. 60 yr. Widespread cerebral metastases of lung adenocarcinoma	Same, HE	Same, IH	M. 22 yr. Two metastases of choriocarcinoma (primary in mediastinum)


Same, surgical specimen, HE	Same, IH	F. 15 yr. Three metastases of choriocarcinoma (primary in hydatiform mole)	Same, surgical specimen


F. 27 yr. Diffusely infiltrating, non contrast enhancing B cell lymphoma	Same, HE	Same, IH

Neuro Image Bank »»»
	Skull base with dura mater and cranial nerve roots	Axial sections of intact head, brain in situ.	Coronal sections of intact head, brain in situ.

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31/7/08
New Cases of Neuroimaging & Neuropathology:

M. 46 yr. Cystic frontal pilocytic astrocytoma with abundant vascular proliferation	Same, surgical specimen, HE	Same, special stains	Same, IH - GFAP


Same, VIM, CD34, Ki-67	F. 21 yr. Pilocytic astrocytoma of chiasmatic region and third ventricle	Same, smear, HE, IH	F. 20 yr. Pilocytic astrocytoma of midbrain


Same, HE, special stains. Picture: leptomeningeal invasion and desmoplastic reaction	Same, IH. Picture: leptomeningeal invasion.	M. 68 yr. Pilocytic astrocytoma of midbrain tegmentum and pons with cerebellar extension	Same, HE. Picture: tumor invasion of perivascular Virchow-Robin spaces


F. 2 yr 5 m. Frontal ependymoblastoma	Same, HE	Same, IH	Same, IH, text


M. 56 yr. Subependymoma of lateral ventricle	Same, specimen, HE, special stains	Same, IH, text

10/3/08

Basic Atlas of Human Neuroanatomy

Collaboration of

Dept of Anatomy
IB - UNICAMP

Dept of Pathology
FCM - UNICAMP

6/1/08
New Cases of Neuroimaging & Neuropathology:
M. 36 yr. Anaplastic oligoastrocytoma - radiation brain necrosis after 5 years. Case summary
	First MRI, march 2002. Right sided frontoparietal tumor	Surgical specimen showing vascular proliferation	M. 40 yr. Same patient after 4 years. Radiation induced demyelinating white matter lesions. No tumor recurrence


M. 41 yr. Same, 5 years after surgery - radiation induced pseudotumoral brain necrosis.	Same, surgical specimen, HE	Same, special stains	Same, immunohistochemistry


F. 43 yr. Meningioma of optic nerve sheath. Surgical specimen, HE	Same, special stains	Same, IH	F. 56 yr. Another case of meningioma of optic nerve sheath. MRI for comparison


F. 13 yr. Clear cell meningioma of posterior fossa CT, MRI	Same, HE, special stains, text.	Same, IH	Same, electron microscopy


M. 40 yr. Olfactory neuroblastoma (esthesioneuroblastoma) MRI	Same case, surgical specimen, HE. Pictured: Homer Wright rosette	Same, IH for neural markers	Same, IH for non-neural markers. Pictured: sustentacular cells. Text


Same, EM	M. 11 m. Retroperitonial neuroblastoma metastatic to skull	Same, surgical specimen, HE. Pictured: Homer Wright rosettes	Same, IH


M. 49 yr. Recurrent ependymoma of foramen of Luschka, with hyaline core rosettes	Same, HE, special stains	Same, IH Texts: CD56, CD57	Same, EM


F. 19 yr. Cellular ependymoma of posterior horn of lateral ventricle	Same, surgical specimen, HE.	Same, IH. Pictured: dot pattern in labelling for EMA	Same, EM. Pictured: cilia and microvilli filling ependymal rosette Text: cell junctions

7/11/07
New Cases of Neuroimaging & Neuropathology: Diffuse astrocytomas
Illustrated linked text (in Portuguese)

F. 47 yr. Small low grade frontal astrocytoma (incidental MRI finding).	M. 35 yr. Small low grade frontal astrocytoma in premotor area	F. 30 yr. Low grade frontal astrocytoma with early anaplasia (foci of contrast enhancement)	M. 44 yr. Poorly circumscribed low grade frontal astrocytoma


M. 36 yr. Recurrent frontobasal low grade astrocytoma, 6 yr followup	M. 7 yr. Low grade solid-cystic astrocytoma of hemispheric white matter	M. 43 yr. Diffuse temporal astrocytoma, transtentorial herniation and midbrain compression	M. 52 yr. Diffuse temporal astrocytoma infiltrating brainstem


M. 39 yr. Diffuse low grade temporal astrocytoma with anaplastic recurrence after 4 years	M. 53 yr. Paramedian anaplastic astrocytoma with contralateral extension via corpus callosum	F. 10 yr. Anaplastic astrocytoma of centrum semiovale	F. 54 yr. Low grade astrocytoma of insular region


M. 34 yr. Low grade astrocytoma of insular region	M. 38 yr. Low grade astrocytoma of insular region	F. 40 yr. Low grade astrocytoma of insular region extending into frontal and temporal lobes	M. 52 yr. Low grade astrocytoma of thalamus with secondary infiltration of hippocampus and insula


M. 5 yr. Diffuse low grade astrocytoma of thalamus and basal ganglia	F. 51 yr. Low grade astrocytoma of left thalamus extending into centrum semiovale, corpus callosum and right hippocampus	F. 43 yr. Bilateral thalamic astrocytoma	M. 37 yr. Anaplastic thalamic astrocytoma


F. 46 yr. Low grade periaqueductal astrocytoma	M. 21 yr. Low grade periaqueductal astrocytoma	M. 8 yr. Anaplastic astrocytoma of pons	F. 41 yr. Low grade astrocytoma of pons and medulla


F. 11 yr. Exophytic anaplastic astrocytoma of lateral medulla oblongata	M. 32yr. Low grade astrocytoma of cervical spinal cord	F. 30 yr. Low grade frontal astrocytoma with early anaplasia. Surgical specimen, HE	Same, IH

			Illustrated text linked to cases: Diffuse astrocytomas (in Portuguese)
M. 38 yr. Well circumscribed frontal oligoastrocytoma	Same case, surgical specimen, HE	Same, IH

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27/7/2007
New Cases of Neuroimaging & Neuropathology:
			Illustrated texts (in Portuguese) : Sturge-Weber Sickle cell disease
F. 50 yr. Sturge-Weber syndrome. Calcifications in plain skull X-ray films	M. 12 yr. Sturge-Weber syndrome. Cortical calcifications showing as bands of low signal intensity in T2 WI	M. 1 yr 9 m. Sturge- Weber syndrome. Contrast enhancement of cortical angiomas and choroid plexus in left hemisphere.


F. 25 yr. Sickle cell disease. Infarcts of both middle cerebral artery territories.	M. 13 yr. Sickle cell disease. Infarcts of carotid artery territories. Pictured : bilateral absence of carotid flow on MRA.	M. 22 yr. Sickle cell disease. Infarct of left middle cerebral artery territory	F. 19 yr. Sickle cell disease. Multiple infarts, arterial watershed zone lesions


F. 27 yr. Sickle cell disease. Arterial watershed zone lesions in white matter, with cavitations	M. 31 yr. Sickle cell disease. Arterial watershed zone lesions	M. 18 yr. Sickle cell disease. Lacunae in basal ganglia. Arterial watershed zone lesions	M. 6 m. Sickle cell disease. Extensive hemorrhagic infarction of cerebellar cortex


Papillary craniopharyngioma	Same, HE. Squamous epithelium	Papillary craniopharyngioma (another case)	Same, HE. Cubic epithelium


Heavily calcified oligodendroglioma, 7-year follow up. CT (2000 - 2006)	Same, MRI (2006). Diffuse infiltrative growth, invasion of right hemisphere via corpus callosum	Same, after 8 months (2007). Development of contrast enhancing anaplastic foci	Same, HE. Oligodendroglioma with minigemistocytes
Case summary

Same, IH	Oligodendroglioma of basal cerebral hemisphere	Same. Oligodendroglioma with abundant minigemistocytes, HE, IH	Lepromatous leprosy of sural nerve. HE, special stains, IH

Neuro Image Bank »»»
	Normal cerebral digital angiography	Normal arterial MRA (magnetic resonance angiography)	Normal arterial MRA (another case)


Normal venous MRA	Normal venous MRA (another case)	Normal temporal artery, HE, Masson's trichrome, Verhoeff

Image Bank, other subjects »»»
	Normal membranous ossification in cranial bones	Normal enchondral ossification in vertebral bodies	Placenta in maternal sickle cell disease

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30/5/2007
New Cases of Neuroimaging & Neuropathology:

F. 11 yr. Diffuse astrocytoma of right thalamus with anaplastic foci	Same, HE, IH. Pictured: high proportion of positive nuclei for p53	Secretory meningioma. Electron microscopy. Pictured: pseudopsammomatous bodies	Pilocytic astrocytoma of cerebellum rich in Rosenthal fibers. Electron microscopy


F. 6 yr. Gliomatosis cerebri (anaplastic diffuse astrocytoma of rapid growth). 1st MRI	Same, after 40 days. Multiple foci of contrast enhancement	Same, stereotaxic biopsy, HE, IH. Nuclear atypia, endothelial proliferation, thrombosis	F. 14 yr. Solid-cystic temporal xanthoastrocytoma


Same, HE, glycogen deposits in tumor cell cytoplasm	Same, PAS	Same, IH	Same, EM


F. 18 yr. Central neurocytoma	Same, HE, IH. Pictured: astrocytic differentiation	F. 75 yr. Occipital metastasis of follicular carcinoma of thyroid. 4-year history	Same, HE, IH


Secretory meningioma of sphenoid wing with hyperostosis. CT, MRI	Same, intraosseous, intracranial and intraorbitary components, HE	Same, PAS, IH	Same, EM


M. 25 yr. Systemic T/NK cell lymphoma masquerading as multiple sclerosis	Same, postmortem examination of brain and spinal cord	Same, brain, HE - lymphoma	Same, spinal cord, HE - lymphoma
Case summary	Texts:	NK cells	T/NK lymphomas

Same, spinal cord, HE - other findings. Pictured: cerebellar tonsil herniation down to midthoracic cord	Same, spinal cord, IH - lymphoma	Same, other organs, HE. Pictured: lymphomatous infiltration of spleen arterioles	Same, endocardium, IH. Pictured: nuclear positivity for Epstein-Barr virus encoded RNAs (EBER)


M. 15 yr. Non-Taylor cortical dysplasia + incidental pleomorphic xanthoastrocytoma	Same, temporal lobectomy, gross, HE	Same, dysplastic cortex and white matter, HE	Same, GFAP. Pictured: gliosis of molecular layer
Case summary

Same, VIM	Same, S-100, CD34, NSE. Pictured: abnormal neuron /astrocyte relationship	Same, intracortical pleomorphic xanthoastrocytoma, (chance finding). HE, IH

Neuro Image Bank »»»
	Massive cerebellar herniation into spinal subarachnoid space down to midthoracic level	Corpora amylacea

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2/5/2007
Neuroimaging cases: Neurofibromatosis type 1 (NF1)

M. 23 yr. NF1. Diffuse astrocytoma of cerebellum, sphenoid dysplasia, high signal intensity focus in globus pallidus		M. 10 yr. NF1. Diffuse astrocytoma of optic pathways, gliomatosis of brain stem and cerebral hemispheres


F. 6 yr. NF1. Diffuse astrocytoma of optic pathways, gliomatosis of brain stem and centroencephalic structures, neurofibroma of scalp		F. 9 yr. NF1. Pilocytic astrocytoma of optic nerve


F. 12 yr. NF1. Sphenoid dysplasia, neurofibromas of orbit and scalp, enlarged cisterna magna, foci of abnormal signal intensity in cerebellar vermis and globus pallidus		M. 14 yr. NF1. Multiple foci of abnormal signal intensity ('hamartomas') in brain.


F. 25 yr. NF1. Foci of abnormal signal intensity ('hamartomas') in brain.		M. 11 yr. NF1. Sphenoid dysplasia, neurofibroma of orbit, proptosis, bilateral foci of abnormal signal intensity in globus pallidus


M. 30 yr. NF1. Plexiform neurofibroma, sphenoid dysplasia, middle fossa arachnoid cyst, craniofacial deformity		F. 24 yr. NF1. Plexiform neurofibroma of face and scalp, sphenoid dysplasia, middle fossa arachnoid cyst, craniofacial deformity, proptosis and buphthalmos.


M. 13 yr. NF1. Plexiform neurofibroma of scalp and ear, posterior fossa arachnoid cyst		M. 17 yr. NF1. Plexiform neurofibroma of nuchal region with malignant transformation (malignant peripheral nerve sheath tumor, MPNST).


M. 56 yr. NF1. Multiple tumors of spinal nerve roots		F. 11 yr. NF1. Multiple tumors of spinal roots and nerves extending widely into paravertebral muscles


M. 66 yr. NF1. Lateral meningoceles of thoracic and sacral regions, marked kyphoscoliosis, cutaneous neurofibromas.

Neurofibromatosis type 2 (NF2)

M. 11 yr. NF2. Bilateral vestibular schwannomas, ependymoma of medulla and cervical cord, meningiomas of foramen of Luschka and lateral ventricle.		M. 25 yr. NF2. Bilateral vestibular schwannomas, ependymoma of cervical cord, cavernous sinus meningioma (arrow), optic nerve sheath tumor (also meningioma?)


F. 51 yr. NF2. Multiple meningiomas (meningiomatosis), left vestibular schwannoma , ependymoma of spinobulbar transition.

			Illustrated linked texts (in Portuguese): schwannomas, neurofibromas, NF1, NF2.
M. 42 yr. NF2. Left vestibular schwannoma, meningioma of petrous apex and sphenoid, tentorial meningioma surrounding straight sinus

Neuro image bank »»»
	Normal skull base and orbit (bone specimens).	Normal sphenoid bone	Axial CT scan of normal skull base, bone settings

23/2/2007
New Cases of Pilocytic Astrocytoma - Neuroimaging & Neuropathology:

Pilocytic astrocytomas of cerebellum, 3 cases, CT	Pilocytic astrocytoma of cerebellar vermis	Pilocytic astrocytoma of cerebellar vermis, another case	Same, classical biphasic histological pattern. HE, IH


Pilocytic astrocytoma of cerebellar hemisphere	Pilocytic astrocytoma of cerebellar hemisphere	Pilocytic astrocytoma of cerebellar hemisphere. 17-year follow-up	Intraventricular pilocytic astrocytoma


Infiltrating cystic pilocytic astrocytoma of vermis in a 72 year-old man	Same, infiltration of cerebellar cortex. HE, IH	Aggressive pilocytic astrocytoma of cerebellum with extensive meningeal infiltration	Same, exuberant endothelial proliferation. HE, IH


Pilocytic astrocytoma of cerebellar vermis with ventricular seeding. 3-year follow-up			Same, classical biphasic histological pattern. HE, IH


Pilocytic astrocytoma of quadrigeminal plate	Pilocytic astrocytoma of quadrigeminal plate, another case	Pilocytic astrocytoma of optic nerve	Pilocytic astrocytoma of optic nerve. Extension to optic chiasm


Pilocytic astrocytoma of hypothalamic region	Pilocytic astrocytoma of optic chiasm and hypothalamic region, anaplastic recurrence	Pilocytic astrocytoma of optic chiasm growing into third ventricle	Pilocytic astrocytoma of basal cerebral hemisphere


Pilocytic astrocytoma of optic chiasm with third ventricle extension	Same, with pilocytic and fibrillary histological patterns, the latter with gemistocytic astrocytes. HE, IH	Pilocytic astrocytoma of basal cerebral hemisphere recurring after 4 months	Same, highly cellular pilocytic pattern


Pilocytic astrocytoma of deep cerebral hemisphere with explosive growth in 4 months	Same, pilocytic pattern with intense nuclear atypia	Pilocytic astrocytoma of frontal pole	Same, exuberant endothelial proliferation. HE, IH


Pilocytic astrocytoma of thoracic/lumbar spinal cord	Same, predominance of diffuse pattern with hyalinized vessels	Pilocytic astrocytoma of cervical/thoracic spinal cord	Pilocytic astrocytoma of brain stem and cervical spinal cord

Neuro Image Bank »»»		Illustrated Text: pilocytic astrocytomas (in English) .
	Optic nerve glioma (pilocytic astrocytoma)

4/1/2007
New Cases of Neuroimaging & Neuropathology:

Echinococcosis of the central nervous system. CT, MRI	Same, post mortem examination	Same, scanned microscopical slides	Same, histology, text


Pseudotumoral multiple sclerosis. CT, MRI	Same, scanned microscopical slides, HE histology	Same, IH.


Multiple sclerosis. Acute phase lesions with contrast enhancement	Multiple sclerosis. Typical lesions in corpus callosum and corona radiata	Multiple sclerosis. Chronic demyelinating lesions in centrum semiovale	Multiple sclerosis. Lesions in corpus callosum and hemispheric white matter


Multiple sclerosis. Severe case with widespread multifocal demyelination	Multiple sclerosis. Lesions in pons, cerebellum and internal capsule.	Acute disseminated encephalomyelitis (ADEM), pseudotumoral form


Central pontine myelinolysis	Same, stereotaxic biopsy. Text	Central pontine myelinolysis (another case)	Osteosarcoma of clivus secondary to irradiation for craniopharyngioma


Same, HE	Gliomatosis cerebri initiating as left hemispheric oligoastrocytoma. Early CT, 6/2004	Same, focus of annular enhancement in right hemisphere. MRI 4/2006	Same after two months: tumor dissemination in right hemisphere. MRI 6/2006


Ganglioglioma with sarcomatous component, CT	Same, MRI	Same, HE, special stains	Same, IH


Non Langerhans histiocytosis of skull base and sellar region. Early lesions CT, MRI	Same, follow up MRI after 4 months	Same, HE, IH	Non Langerhans histiocytosis of meninges and brain. Early lesions, MRI


Same, follow up MRI after 6 months	Same, HE, IH	Langerhans histiocytosis (eosinophil granuloma) of skull and sternum	Same, HE, IH. Text

Neuro Image Bank »»»
	Creutzfeldt-Jakob disease. Post mortem examination of brain	Creutzfeldt-Jakob disease. Another case, autopsy findings.	Same, HE. Text


Multiple sclerosis - macroscopical PM specimens	Multiple sclerosis - scanned microscopical slides	Multiple sclerosis - microscopy	Multiple sclerosis - macro/microscopical comparisons. Text


Amyotrophic lateral sclerosis or motor neuron disease - macroscopical PM specimens, scanned microscopical slides	Same, microscopy. Text	Chronic subdural hematoma (incidental autopsy finding)

Additions of 2004 to 2006

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Updated 5/1/2020	General and Special Pathology	e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

......