Neupatimagem UNICAMP

Pathology - Neuropathology - Neuroimaging
New additions (2017, 2018) ..

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Updated 5/1/2020	General and Special Pathology	e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

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22/11/18
New Cases of Neuroimaging & Neuropathology:

M. 5 yr 5 m. Desmoplastic medulloblastoma with rhabdomyoblastic differentiation (medullomyoblastoma) CT, MRI	Same, macro	Same HE, reticulin. Text	Same IH - desmin, 1A4


Same, GFAP, vimentin, S-100	Same, synaptophysin, chromogranin, MAP2	Same, CD56, INI-1, Ki67, p53


M. 8 yr 10 m Pleomorphic xanthoastrocytoma. MRI	Same, macro	Same, HE, Masson	Same, IH - GFAP, vimentin, synaptophysin, CD34, Ki67, p53


M. 3 yr 9 m. Clear cell meningioma of cauda equina. MRI.	Same, HE, Masson, reticulin	Same, IH - EMA, S-100 Ki67, p53. Text


F. 3 yr. Tuberculoma of thalamus. MRI	Same, macro.	Same, HE	Same, Ziehl-Neelsen


M. 5 yr 5 m Mature teratoma of pineal. MRI	Same, macro	Same, HE	Same, Masson


F. 44 yr. Cerebral neuroenteric cyst. MRI	Same, HE	Same, IH - AE1AE3, CK7, CK20, EMA, GFAP, vimentin. Text

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9/9/18
New Cases of Neuroimaging & Neuropathology:

M. 5 yr 2 m. Melanotic medulloblastoma of cerebellar vermis Original MRI	Same, 2 1/2 months after surgery and radiotherapy. Extensive local recurrence and leptomeningeal spread	Same, HE, text	Same, IH - GFAP, VIM, S-100, HMB-45


Same, IH - SNF, NF, CD34, Ki67		F. 7 m. Atypical teratoid/rhabdoid tumor of cerebellar vermis	Same, HE. Text ATRT


Same, IH - GFAP, VIM,	Same, IH - EMA	Same, IH - AE1AE3	Same, IH - 1A4


Same, IH - SNF, NF	Same, IH - INI-1, CD34, Ki67


F. 7 yr 6 m. Temporo-occipital dysembryoplastic neuroepithelial tumor (DNT)	Same, HE	Same, IH - GFAP, VIM, synaptophysin, chromogranin, NF, CD34, Ki67. Pictured - 'floating neuron'


F. 3 yr 4 m. Malignant rhabdoid tumor of kidney. CT, MRI	Same, HE	Same, IH - vimentin, cytokeratins	Same, IH - EMA, HHF35


Same, IH - INI-1, Ki67. Text - Malignant rhabdoid tumor of kidney		F. 4 yr 3 m. Same case - cerebral metastasis one year after complete clearing of systemic lesions by chemotherapy	Same, HE


Same, IH - VIM, AE1AE3	Same, IH - EMA,	Same, IH - 1A4	Same, IH - S-100, CD56


Same, IH - NF	Same, IH - INI1, CD34, Ki67, p53


M. 17 yr 2 m. Recurrent cerebral metastases of yolk sac tumor of testis. Third lesion at same site within one year	Same, HE. Pictured - Schiller-Duval body	Same, IH - AE1AE3, a-FP, VIM	Same, IH - CD34, Ki67, p53, INI-1

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7/7/18
New Cases of Neuroimaging & Neuropathology:

F. 8 yr 5 m. Rosai-Dorfman disease of brain (non-Langerhans histiocytosis). CT, MRI	Same, HE. Text. Pictured - emperipolesis	Same, IH - S100, CD45, CD3, CD20, CD68, CD1A	Same, IH - GFAP, SNF, NF, CD34, Ki67


F. 4 yr 1 m. Anaplastic ganglioglioma of thalamus (grade III) evolving to grade I after radio- and chemotherapy	Same, comparison of two samples 10 months apart (before and after treatment); HE of first sample	Same, IH of first sample - GFAP, VIM, SNF, NF, CD34, Ki67, p53	Same, HE of second sample


Same, IH of second sample - GFAP, VIM, SNF, NF, CD34, Ki67, p53		F. 11 yr 1 m. Ganglioglioma of deep cerebral white matter. CT, MRI	Same, HE, IH. - SNF, NF, GFAP, VIM, CD34, Ki67


M. 6 yr 3 m. Ganglioglioma of cervicothoracic spinal cord	Same, HE	Same, IH - SNF, NF, GFAP, CD34, Ki67. Comment


M. 3 yr 1 m. Choroid plexus carcinoma of right lateral ventricle. CT, MRI	Same, HE, reticulin	Same, IH - AE1AE3, GFAP, VIM, S-100.	Same, IH - SNF, CD34, Ki67, p53


F. 3 yr. Choroid plexus carcinoma of right lateral ventricle before and after chemotherapy. CT, MRI	Same, post treatment specimen - macro, HE	Same, Masson, IH - AE1AE3, vimentin	Same, IH - GFAP, EMA, CD56, CD34, Ki67, p53

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14/5/18
New Cases of Neuroimaging & Neuropathology:

M. 16 yr. Yolk sac tumor of testis with two brain metastases at different times	Same, primary tumor in testis, HE, immunohistochemistry. Pictured - Schiller-Duval corpuscle. Text. Alpha-fetoprotein	First brain metastasis, HE, IH.	Second brain metastasis, HE, IH. Pictured - hyaline droplets


M. 7 m. 28 d. Desmoplastic infantile ganglioglioma (DIG).	Same, macro, HE	Same, special stains. Text. Desmoplastic infantile ganglioglioma and astrocytoma	Same, IH


M. 19 yr. Embryonal carcinoma originating in immature teratoma of testis. Two brain metastases at different times	Same, primary tumor in testis and lymph node metastasis (both immature teratoma). HE. Texts: mature and immature teratomas, mixed germinal tumors	Same, two metachronous brain metastases of embryonal carcinoma. HE. Text - embryonal carcinoma	Same, first brain metastasis, IH. Text - CD30


F. 6 yr. 8 m. Classical medulloblastoma in fourth ventricle; retrograde seeding of third ventricle mimicking germinoma	Same, HE	Same, IH

20/3/18
New Cases of Neuroimaging & Neuropathology:

M. 9 yr 6 m. Classical medulloblastoma in cerebellar vermis, rich in nuclear palisading and Homer Wright pseudorosettes	Same, HE	Same, temporal lobe metastasis after 8 years, no recurrence at primary site	Same, metastasis, HE, faithfully recapitulating primary tumor


Same, temporal cortex infiltration (perineuronal satellitosis)		M. 15 yr. Germinal cell tumor of III ventricle (germinoma in small biopsy)	Same, HE, IH - PLAP, c-Kit, OCT4, GFAP, VIM, AE1AE3, Ki67, p53


M. 5 yr 3 m. Primitive neuroectodermal tumor (PNET) of temporal lobe	Same, tumor: macro specimen, HE, IH - GFAP, VIM, CD56, CD34, Ki67, p53	Same, infiltrated temporal cortex. HE, IH - GFAP, NF, p53


F. 5 yr. Classical medulloblastoma in cerebellar vermis	Same, HE, IH - GFAP, SNF	Same, aged 14 years. Recurrence at primary site after 9 years : small foci of high signal intensity in diffusion sequence,	progression via III ventricle and foramina of Monro to large frontal lobe metastasis


Same, frontal lobe recurrence, HE, Masson, reticulin	Same, IH - GFAP, VIM, SNF, Ki67

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15/1/18
New Cases of Neuroimaging & Neuropathology:

M. 2 m 12 d Medulloblastoma with extensive nodularity	Same, HE, reticulin, Text	Same, GFAP, VIM	Same, SNF, MAP2, CD56


Same, CD34, Ki67	F. 1 yr 1 m Sacrococcygeal teratoma with yolk sac tumor (or endodermal sinus tumor) component	Same, HE, PAS, texts, (sacrococcygeal teratoma , yolk sac tumor)	Same, IH - alpha-fetoprotein, AE1AE3, VIM, Ki67


M. 1 yr 3 m. Diffuse multicystic ganglioglioma in cerebellum	Same, Macro, HE	Same, GFAP	Same, VIM


Same, SNF	Same, MAP2. Arrow - tumor infiltrating cerebellar pia mater	Same, NF, CD34, Ki67


F. 10 yr 4 m Cerebellar ganglioglioma with pilocytic glial component + NF1	Same, Macro, HE	Same, IH - GFAP, VIM, SNF, MAP2, tubulin, CD34, Ki67


M. 10 yr 2 m. Ectopic subcutaneous myxopapillary ependymoma of sacral region	Same, Macro, HE	Same, Masson, reticulin, Alcian blue, PAS	Same, IH - EMA, GFAP, VIM, S-100, AE1AE3, Ki67


M. 12 yr. Giant cell reparative granuloma of mastoid	Same, Macro, HE, Masson, Reticulin, text	Same, IH - CD68, VIM, 1A4, CD34, Ki67, text (myofibroblasts)

30/9/17
New Cases of Neuroimaging & Neuropathology:

F. 1yr 1m. Anaplastic ganglioglioma in III ventricle. Original biopsy and after 6 months of chemotherapy	Same, 1st sample, HE	Same, 1st sample, IH - GFAP, VIM, SNF, NF, SMI32, CD34, Ki67	Same, 2nd sample, HE


Same, 2nd sample, IH - GFAP, SNF, NF, SMI32, CD34, Ki67		M. 19 yr. Diffuse low grade astrocytoma of thoracic spinal cord. Spread to cauda equina and frontal metastasis	Same, HE, IH - GFAP, Ki67
		MRIs in detail

F. 1yr 3m. Extensive thoracic myxopapillary ependymoma	Same, HE, text	Same, Masson's trichrome, Alcian blue	Same, IH - GFAP, VIM, S100, CD34, Ki67


M. 6 yr. Langerhans cell histiocytosis (histiocytosis X or eosinophil granuloma) of skull (occipital bone)	Same, HE, IH - CD1A, S100, CD68, CD20, CD3, Ki67	F. 2yr 9m. Langerhans cell histiocytosis in vertebral body of C7	Same, HE, IH - CD1A, S100, CD68, Ki67


F. 14 yr. Colloid cyst of III ventricle	Same, gross specimen, HE, Masson's trichrome	Same, IH - AE1AE3, 34bE12, 35bH11, CK7, EMA, CD68, VIM, Ki67


M. 55 yr. Colloid cyst of III ventricle	Same, HE	Same, IH - AE1AE3, 34bE12, CK7, CK20, CD68, Ki67


F. 22 yr. Colloid cyst of III ventricle	Same, HE, Masson's trichrome, IH - AE1AE3, 34bE12, EMA, Ki67		M. 2yr. 8m. Anaplastic ganglioglioma of brain stem revisited. Neoplastic seeding of peritoneum via CSF drainage catheter after 4 months. HE, IH - GFAP, CD20, CD3, CD68, Ki67. Atypical cells in ascitic fluid

......

13/6/17
New Cases of Neuroimaging & Neuropathology:

M. 7 yr. 8 m. Cerebral meningioangiomatosis MRI, CT	Same, surgical pictures, macro specimen	Same, HE, text	Same, Masson's trichrome, reticulin


Same, LFB-Nissl	Same, IH - neuronal antigens - MAP2, NeuN, SMI32	Same, IH - GFAP, VIM	Same, IH - CD34, Ki67


M. 10 m. Choroid plexus papilloma of lateral ventricle	Same, macro, text - choroid plexus tumors	Same, HE	Same, HE, cerebral infiltration


Same, IH - GFAP, VIM, S-100, AE1AE3	Same, IH - synaptophysin, chromogranin, CD56	Same, IH - CD34, Ki-67, p53

	F. 3 m. 15 d. to 3 yr. 4 m. Anaplastic congenital glioma with spontaneous maturation and regression. 3-year follow-up Case summary
		Same, CTs, MRIs at various times


Same, 1st biopsy, HE	Same, IH - GFAP, VIM	Same, IH - SMI-32, chromogranin, synaptophysin	Same, IH - CD34, Ki-67, p53


Same, 2nd biopsy, HE	Same, IH - GFAP, VIM	Same, IH - SMI-32, chromogranin, synaptophysin, NF	Same, IH - CD34, Ki-67, p53


F. 2 yr 9 m. Embryonal tumor with abundant neuropil and multilayered rosettes. Recurrence after 6 months. MRI		Same, HE	Same, Masson's trichrome, reticulin

			Same case, original tumor CT, MRI HE, IH, EM
Same, IH - neuronal antigens - chromogranin, SMI-32, NF, synaptophysin, NeuN	Same, IH - glial antigens - GFAP, VIM	Same, IH - CD34, Ki-67, p53

.....

20/1/17
New Cases of Neuroimaging & Neuropathology:

M. 2 yr. 4 m. Anaplastic ganglioglioma of brain stem. MRI	Same, HE, text	Same, Masson's trichrome, reticulin	Same, immunohistochemistry for GFAP, VIM


Same, IH - neuronal antigens, CD34, Ki67	Same, arachnoid cyst (incidental finding)


M. 18 yr. Dermoid cyst of posterior fossa insinuating into foramen magnum and compressing medulla. CT, MRI	Same, gross specimen	Same, HE


F. 79 yr. Gangliocytoma of pituitary. CT, MRI	Same, HE, text	Same, Masson's trichrome, reticulin	Same, IH - MAP2, SMI-32, NF


Same, IH - GFAP, AE1AE3, GH, CD34, Ki67		F. 47 yr. Cysticercus racemosus of brain. CT	Same, HE


F. 46 yr. Progressive multifocal leukoencephalopathy (PML). MRI	Same, HE, LFB-Nissl	Same, IH - GFAP, S-100	Same, IH - CD68, CD3, CD20


Same, IH - Ki67, p53	Same patient has low-grade B cell lymphoma. CT - splenomegaly	Same, bone marrow biopsy - scattered paratrabecular B-lymphocyte aggregates


M. 46 yr. Eosinophil pituitary adenoma causing acromegaly. Negative IH for HGH in spite of increased serum levels. CT, MRI	Same, gross specimen	Same, HE	Same, IH - GH (text), prolactin, AE1AE3, Ki67. Pictured - GH positive cells from remaining pituitary, GH negative adenoma


Same, electron microscopy. Text - secretory granules.		F. 2 yr. 2 m. Embryonal tumor with abundant neuropil and multilayered rosettes. Revisited for addition of electron microscopy

Additions of 2004 to 2006

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Updated 5/1/2020	General and Special Pathology	e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

......