Neupatimagem UNICAMP

Pathology - Neuropathology - Neuroimaging
Additions posted 2011 - 2012 ....

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Updated 5/1/2020	General and Special Pathology	e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

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20/12/12
New Cases of Neuroimaging & Neuropathology:

F. 20 yr. Dysembryoplastic neuroepithelial tumor (DNT) of right superior frontal gyrus. MRI, surgical field pictures, specimen	Same, HE. Text	Same, Masson's trichrome	Same, luxol fast blue - cresyl violet


Same, IH for neurons - MAP2	Same, IH for neurons - NF, tubulin	Same, IH for astrocytes - GFAP, VIM, S-100	Same, IH - CD34, Ki67


M. 13 yr. DNT of left pre-central gyrus	Same, HE - pictured : perineuronal satellitosis	M. 24 yr. DNT of left cingulate gyrus at genu of corpus callosum	M. 9 yr. DNT of antero-medial right temporal lobe


F. 8 yr. DNT of basal gyri of left temporal lobe	F. 7 yr. DNT of left cuneus	M. 29 yr. DNT of isthmus of right cingulate gyrus. 9-year followup	F. 30 yr. DNT of antero-medial left temporal lobe


F. 32 yr. DNT of right middle frontal gyrus	F. 8 yr. DNT of left middle and inferior temporal gyri


F. 68 yr. Exophytic meningioma of lesser sphenoid wing with hyperostotic nodule at implantation	Same, specimen, HE	Same, Masson's trichrome	Same, hyperostotic nodule under polarized light


M. 64 yr. Dermoid cyst (mature teratoma) in cerebellar vermis + posterior fossa arachnoid cyst	Same, specimen, HE

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5/12/12
New Cases of Neuroimaging & Neuropathology:

F. 64 yr. Bifrontal desmoplastic ganglioglioma above the corpus callosum with areas of central neurocytoma	Same, ganglioglioma component - gross specimen, smear, paraffin HE	Same, special stains	Same, immunohistochemistry for astrocytes - GFAP, VIM
Case summary


Same, IH for neurons - MAP2, NF	Same, IH for neurons - chromogranin, synaptophysin, class III beta tubulin, NeuN	Same, IH - CD34, Ki67, p53	Same, electron microscopy - neurons


Same, EM - dendrites, axons, neuropil, synapses	Same, EM - astrocytes, granular bodies, capillary	Same, central neurocytoma component. HE	Same, IH for astrocytes - GFAP, VIM


Same, IH for neurons - NF, chromogranin, synaptophysin	Same, IH for neurons - MAP2, NeuN	Same, IH, nestin, CD34, Ki67, p53


M. 30 yr. Hemangiopericytoma of tentorium cerebelli	Same, HE	Same, special stains	Same, IH


Same, EM. Pictured - reticulin fibers

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18/9/12
New Cases of Neuroimaging & Neuropathology:

F. 43 yr. Supratentorial primitive neuroectodermal tumor (PNET). MRI 2 ½ months after first operation	Same, first sample, HE	Same, second sample, HE	Same, special stains


Same, immunohistochemistry for GFAP, VIM, nestin	Same, IH, tubulin (text), CD56, S-100, NF	Same, IH, CD68, HAM-56, CD3, CD20	Same, IH, CD34, 1A4, Ki67, p53


Same, electron microscopy		M. 25 yr. Ganglioglioma exceptionally rich in eosinophilic granular bodies (EGBs)	Same, HE


Same, special stains	Same, IH - synaptophysin, NF. Pictured - binucleated neuron	Same, IH - GFAP, VIM	Same, IH - CD34, Ki-67. Pictured -'feathery cell'


M. 58 yr. Basilar artery thrombosis in sickle cell disease	Same, pontine infarction	Same, HE - coagulation and liquefaction necrosis, sickled red blood cells in basis pontis	Same, basilar artery thrombus under stereomicroscope and in HE stain


Same, spleen, liver, kidney, lung, HE		M. 62 yr. Progressive multifocal leucoencephalopathy (PML)	Same, HE (needle biopsy). Pictured - atypical astrocytes
		Text (PML)	Text - HIV encephalopathy

M. 25 yr. Progressive multifocal leucoencephalopathy (PML) affecting cerebellum and brain stem	M. 41 yr. Progressive multifocal leucoencephalopathy (PML)	M. 47 yr. HIV encephalopathy	M. 52 yr. HIV encephalopathy

14/8/12
New Cases of Neuroimaging & Neuropathology:

M. 54 yr. Cerebral histoplasmosis. MRI 9/2011. Hydrocephalus, small periventricular lesions	Same, MRI 3/2012. Obliteration of third ventricle	Same, CT 3/2012. Small calcified nodule in right anterior horn of lateral ventricle
Case summary, text.


Same, gross brain pathology. Exudative and hemorrhagic lesions in third ventricle	*Same, HE, third ventricle lesions. Histoplasma capsulatum* fungi in macrophage phagosomes**	Same, HE, gliotic / fibrotic lesion at anterior commissure (detected on MRI 6 months previously)	Same, HE, necrotic calcified nodule at right anterior horn of lateral ventricle (also visible on MRI 6 months previously)


Same, HE, fourth ventricle and leptomeningeal lesions - vasculitis, ependymitis, radiculitis	Same, Masson's trichrome. Fibrosis of basal leptomeninges	Same, techniques for fungi - Grocott + HE, Grocott + light green, PAS	Same, IH for inflammatory cells : CD68, HAM-56, CD3, CD20


Same, IH for nerve tissue : GFAP, NF (pictured - axons among fungi-filled macrophages)	Same, electron microscopy


M. 44 yr. Oncocytoma (null cell adenoma) of pituitary	Same, HE	Same, IH. TSH detectable in few cells, other hormones negative	Same, EM. Tumor cell rich in abnormal mitochondria, rare secretory granules

New slides for undergraduate Pathology classes »»»
	A. 271a. Gastric intramucous signet ring adenocarcinoma	A. 98a. Arteriolar hyaline change of kidney in benign hypertension	A. 98a. Glomerular hyaline change in benign hypertension


A. 72b. Biliary cirrhosis. Bilirubin in dilated intrahepatic bile ducts.	A. 317a. Early organizing thrombus in femoral vein, recanalized thrombus in artery	A. 317a. Same, Masson's trichrome.	A 193a. Leiomyosarcoma. Nuclear atypia, mitoses

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3/6/12
New Cases of Neuroimaging & Neuropathology:

M. 68 yr. Granular cell astrocytoma of brain. CT, MRIs 2011	Same, MRI, post-operative followup after one year.	Same, HE	Same, special stains : Masson's trichrome, PAS
Case summary, text.


Same, immunohistochemistry for GFAP	Same, IH, VIM, nestin	Same, CD34	Same, CD68, HAM-56


Same, S-100, NF, CD99	Same, Ki-67, p53	Same, electron microscopy, glutaraldehyde-fixed	Same, EM, from selected paraffin block


M. 59 yr. Granular cell astrocytoma of brain. HE	Same, IH, GFAP, VIM, S-100	Same, IH, CD34, Ki-67, p53


F. 20 yr. Epidural thoracic ganglioneuroblastoma	Same, HE, text	Same, IH

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26/3/12
New Cases of Neuroimaging & Neuropathology:

F. 37 yr. Intracranial solitary fibrous tumor developing multiple bone metastases 3 years after craniotomy	Same, primary tumor, HE	Same, special stains	Same, IH


Same, vertebral metastasis at T11 with cord compression 3 years later	Same, metastasis, HE, special stains	Same, metastasis, IH


M. 21 yr. Primary meningeal sarcoma with polyphenotypic antigen expression	Same, HE	Same, special stains	Same, IH, muscle antigens, vimentin


Same, IH, epithelial antigens	Same, IH, neural antigens	Same, IH - CD34, Ki-67, p53


M. 51 yr. Secretory meningioma at cerebello-pontine angle masquerading as schwannoma on MRI	Same, HE, special stains	Same, IH


M. 43 yr. Giant bilateral fronto-parietal meningioma with hyperostosis and brain compression (MRI Feb 2008)	Same, midline section through infiltrated bone, HE. Excision of intracranial component deferred due to profuse bleeding	Same, 4 years later. Tumor growth through bone gap and under scalp (MRI Oct 2011)	Same, intracranial tumor specimen weighed 290 g HE


M. 69 yr. Frontal meningioma with hyperostosis and bone destruction	Same, HE - intraosseous component. Ischemic necrosis of tumor and bone trabeculae	Same, HE - intracranial component. Cerebral infiltration

17/2/12
New Cases of Neuroimaging & Neuropathology:

F. 58 yr. Giant cell glioblastoma with a component of conventional glioblastoma multiforme	Same, surgical specimen. Encapsulated tumor with necrotic center	Same, giant cell part - HE, Masson's trichrome	Same, giant cell part - IH - glial markers, GFAP, VIM, S-100


Same, giant cell part - IH - neuronal markers, synaptophysin, chromogranin, NF, class III beta-tubulin	Same, giant cell part - IH - MAP2, CD34, Ki-67, p53	Same, conventional glioblastoma part - HE	Same, conventional glioblastoma part - IH - glial markers, GFAP, VIM


Same, conventional glioblastoma part - IH - neuronal markers, NF, MAP2, tubulin. Pictured - neoplastic infiltration among axons	Same, conventional glioblastoma part - IH - CD34, Ki-67, p53		F. 45 yr. Left parietal ganglioglioma


Same, HE. Pictured - multinucleated tumor cell	Same, IH - glial markers, GFAP, VIM	Same, IH - neuronal markers, synaptophysin, NF, chromogranin, NeuN	Same, IH - MAP2, tubulin, CD34, Ki-67


M. 12 yr. Small solid ganglioglioma of right insula	Same, HE. Pictured - abnormal neuron	Same, IH - glial markers, GFAP, VIM	Same, IH - neuronal markers, synaptophysin, NF, chromogranin, NeuN


Same, IH - MAP2, tubulin, CD34, Ki-67		F. 51 yr. Solid-cystic ganglioglioma of right temporal and occipital regions	Same, HE, Masson's trichrome. Pictured - multinucleated tumor cell


Same, IH - glial markers, GFAP, VIM	Same, IH - neuronal markers, synaptophysin, chromogranin, NF, NeuN	Same, IH - MAP2, tubulin, CD34, Ki-67

.....

18/12/11
New Cases of Neuroimaging & Neuropathology:

M. 24 yr. Atypical central neurocytoma	Same, HE, special stains. Pictured : atypical mitosis. Comment.	Same, IH neuronal markers. Pictured : synaptophysin-positive perivascular pseudorosettes	Same, IH glial markers, CD34, Ki-67 (> 50%)


M. 28 yr. Subependymal giant cell astrocytoma (SEGA) unassociated with tuberous sclerosis	Same, HE - smear, paraffin. Comment. Texts: SEGA, Tuberous sclerosis	Same, IH glial markers	Same, IH neuronal markers


Same, IH nestin, EMA, CD34, Ki-67		M. 26 yr. Central neurocytoma	Same, HE, IH


M. 35 yr. Central neurocytoma	Same, HE. Text: Central neurocytoma	Same, IH neuronal markers, CD34	Same, IH glial markers, Ki-67


F. 44 yr. Ectopic invasive pituitary adenoma centered in sphenoid sinus, spilling into left nasal cavity. Normal sella turcica	Same, specimen, HE. Pictured - nuclear atypia. Text : ectopic pituitary adenoma	Same, special stains. Pictured : mucus filled nasal glands trapped within the adenoma	Same, IH. Pictured : positivity for growth hormone in adenoma cells


F. 54 yr. Cerebro-spinal sarcoidosis	Same, HE, special stains. Text : systemic and CNS sarcoidosis	Same, IH

11/11/11
New Cases of Neuroimaging & Neuropathology:

M. 48 yr. Primary necrotizing vasculitis of central nervous system	Same, in situ view at surgery, HE	Same, special stains	Text : primary angiitis of brain


M. 16 yr. Left frontal cavernoma, first bleeding. Case summary, CT scans	Same, early phase MRI	Same, control after one year	Same, new bleeding (2 years from onset)


Same, surgical specimen under stereomicroscope	Same, HE	Same, Masson's trichrome	Text : vascular malformations of the central nervous system: telangiectasias, cavernomas, AVMs.


F. 28 yr. Cavernoma of right cingulate gyrus	Same, surgical specimen under stereomicroscope	Same, HE, Masson's trichrome


F. 46 yr. Bilateral frontal gliomatosis cerebri involving genu of corpus callosum	Same, HE, immunohistochemistry	F. 42 yr. Centroencephalic diffuse large B-cell lymphoma	Same, HE, IH
	Text : gliomatosis cerebri		Text : primary lymphomas of CNS


M. 28 yr. Papillary craniopharyngioma	Same, HE	Same, Masson's trichrome

......

18/9/11
New Cases of Neuroimaging & Neuropathology:

F. 52 yr. Anaplastic parietal ganglioglioma	Same, macro specimen, smear, scanned slides	Same, HE	Same, IH : glial markers (GFAP, VIM, S-100); nestin


Same, neuronal markers, CD34, Ki67		M. 55 yr. Frontal ganglioglioma with pilocytic glial component	Same, HE : smear, paraffin


Same, IH : GFAP, VIM	Same, IH : MAP2, chromogranin, NeuN, neurofilament	Same, IH : nestin, CD34, Ki67	Text : gangliogliomas


M. 52 yr. Sinonasal neuroendocrine carcinoma	Same, specimen, HE	Same, IH : epithelial markers, vimentin	Same, IH : neural markers
Texts about neuroepithelial tumors of the nasal cavity and paranasal sinuses : olfactory neuroblastoma (1) (2); neuroendocrine carcinoma, sinonasal undifferentiated carcinoma (SNUC).


M. 63 yr. Langerhans cell histiocytosis of orbit	Same, HE	Same, IH	Same, EM

		Texts about : macrophages, dendritic cells, Langerhans cells, Birbeck granules, Langerin, histiocytoses, Langerhans cell histiocytosis, CD1a, CD68.
M. 37 yr. Langerhans cell histiocytosis of spinal canal C7-T1, HE	Same, IH

....

22/8/11
New Cases of Neuroimaging & Neuropathology:

M. 70 yr. Atypical meningioma with intra and extracranial growth replacing left side of frontal bone	Same, HE - hipercellularity, small cells, prominent nucleoli	Same, immunohistochemistry. Pictured: EMA positivity in tumor cell membranes.


F. 63 yr. Giant meningioma of olfactory groove	Same, HE : nuclear palisading mimicking schwannoma	F. 57 yr. Meningioma en plaque of middle fossa infiltrating cavernous sinus and middle ear	Same, HE : whorls in middle ear biopsy


M. 60 yr. Metastatic melanoma in genu of corpus callosum mimicking butterfly glioma	Same, HE	Same, IH. Pictured: HMB-45 positivity in isolated tumor cell	Texts: HMB-45, brain metastases


M. 49 yr. Cerebellar abscess by the fungus Paracoccidioides brasiliensis	Same, HE - double membrane yeasts, multiple budding	Same, Grocott + hematoxylin	Same, Grocott + light green, PAS + hematoxylin


M. 71 yr. Cerebellar abscess caused by Paracoccidioides brasiliensis	Same, smear : HE, Grocott, Papanicolaou	Same, cell block : HE, Grocott


	Image bank, inflammations, digestive tract »»»
		Helicobacter pylori in gastric biopsy. Warthin-Starry silver stain

11/6/11
New Cases of Neuroimaging & Neuropathology:

M. 38 yr. Mucormycosis of nasal cavity, orbit and brain	Same, HE	Same, special stains : Grocott + hematoxylin, Grocott + HE	Same, Grocott + light green, PAS + hematoxylin
			Text: Mucormycosis

M. 63 yr. Paracoccidioidomycoma of cerebellopontine angle	*Same, HE. Pictured : Paracoccidioides brasiliensis* in giant cells**	Same, plain Grocott, Grocott + HE	Same, Grocott + hematoxylin


Same, plain PAS, PAS + hematoxylin		F. 44 yr. Tanycytic ependymoma of lumbar spinal cord	Same, HE


M. 42 yr. Primary extracerebral meningeal glioma	Same, HE	Same, HE, Perls	Same, IH
			Text: Primary extracerebral meningeal glioma
Neuro Image Bank »»»
	Cerebral chromomycosis (cladosporiosis). HE	Same, Grocott + hematoxylin	Same, Grocott + light green, Masson's trichrome
			Text: Chromomycosis
Inflammation Image Bank

Pulmonary cryptococcosis - small subpleural focus. Incidental autopsy finding. HE	Same, special stains : mucicarmine, PAS, Grocott + light green	Pleural and pulmonary mucormycosis. HE	Same, plain Grocott, Grocott + hematoxylin

15/4/11
New Cases of Neuroimaging & Neuropathology:

F. 9 yr. Supratentorial primitive neuroectodermal tumor (PNET)	Same, specimen, HE	Same, special stains. Pictured : elastic fibers amid tumor cells	Same, immunohistochemistry : GFAP, VIM
Case summary, comment, texts: supratentorial PNETs, elastic fibers, nestin

Same, IH : nestin, S100, CD56	Same, IH : synaptophysin, chromogranin, NF, EMA	Same, IH : AE1AE3, 1A4, CD34, Ki-67, p53	Same, electron microscopy. Pictured : elastic fibers


F. 71 yr. Extradural spinal leiomyoma	Same, HE, Masson's trichrome, reticulin	Same, IH. Texts: vimentin, intermediate filaments	Same, EM


M. 55 yr. Temporal pilocytic astrocytoma	Same, HE. Pictured : protoplasmatic area with eosinophilic granular bodies (EGBs)	F. 66 yr. Pilocytic astrocytoma of cerebellar vermis in the 7th decade	Same, HE. Pictured : hyalinized vessels

Previously presented case revisited :
Previously presented case revisited :		M. 49yr. Ependymoma at foramen of Luschka	Same, HE. Ependymoma featuring hyaline centered rosettes containing elastic fibers


Same, special stains. Pictured : grainy elastic fibers in Verhoeff's stain	Same, IH	Same, EM, general features of ependymoma	Same, EM, clumps of elastic fibers at core of 'hyaline rosettes'

5/2/11 Meningiomas - illustrated teaching texts : general features, neuroimaging, gross pathology, microscopy, immunohistochemistry, electron microscopy, meningiomas WHO grade I, grade II and grade III.

Additions of 2004 to 2006

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Updated 5/1/2020	General and Special Pathology	e-mails : gradanat@yahoo.com.br____gradanat@unicamp.br
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

......