Diagnosis: Focal prostatic atrophy
(mergence of complete
and partial atrophy).
Comment:
The
area of complete atrophy in this case is easily discerned (Fig.3) The
basophilic tinge is given due to the scant cytoplasm and the crowded
nuclei. In
contrast to complete atrophy which can typically diagnosed at scanning
magnification,
the area of partial atrophy (Figs. 4 and 5) mimics inifltrative
adenocarcinoma.
The acini of partial atrophy show pale cytoplasm lateral to the nuclei
giving
rise to pale staining glands that more closely mimic cancer, however,
the
nuclei extend to the full cell height, similar to the cytoplasm seen in
adjacent more recognizable benign glands. We can also see luminal
undulations
as constrasted to the straight luminal borders often seen with
malignant glands.
A particular care in interpreting the lesion is the fact that in
partial
atrophy the basal cells are discontinuous and in some acini may be
absent ( Przybycin
CG,
Kunju LP, Wu AJ, et al. Partial atrophy in prostate needle biopsies: A
detailed
analysis of its morphology, immunophenotype, and cellular kinetics. Am J Surg Pathol. 2008;32:58-64). |