Diagnosis: Focal prostatic atrophy (mergence of complete and partial atrophy).



    Comment: The area of complete atrophy in this case is easily discerned (Fig.3) The basophilic tinge is given due to the scant cytoplasm and the crowded nuclei. In contrast to complete atrophy which can typically diagnosed at scanning magnification, the area of partial atrophy (Figs. 4 and 5) mimics inifltrative adenocarcinoma. The acini of partial atrophy show pale cytoplasm lateral to the nuclei giving rise to pale staining glands that more closely mimic cancer, however, the nuclei extend to the full cell height, similar to the cytoplasm seen in adjacent more recognizable benign glands. We can also see luminal undulations as constrasted to the straight luminal borders often seen with malignant glands. A particular care in interpreting the lesion is the fact that in partial atrophy the basal cells are discontinuous and in some acini may be absent  ( Przybycin CG, Kunju LP, Wu AJ, et al. Partial atrophy in prostate needle biopsies: A detailed analysis of its morphology, immunophenotype, and cellular kinetics. Am J Surg Pathol. 2008;32:58-64).